Publications by authors named "D Cournoyer"
Article Synopsis
- Autoimmune diseases generally don’t prevent the use of immune checkpoint inhibitors (ICI) in cancer therapy, but they can lead to various immune-related adverse events (irAEs), including rare conditions like hemophagocytic lymphohistiocytosis (HLH).
- A 79-year-old male with both untreated ankylosing spondylitis and gastric cancer experienced severe symptoms and lab findings indicating HLH after receiving ICIs, despite no signs of infection or hemophagocytosis in a bone marrow biopsy.
- Treatment with glucocorticoids effectively managed the HLH without detracting from the ongoing anti-cancer effects, highlighting the need for further research into how autoimmune conditions and ICIs interact.
Rationale: Richter syndrome (RS) defines the transformation of chronic lymphocytic leukemia (CLL) into a more aggressive lymphoma. Although the term RS is most often reserved for transformation of CLL into diffuse large B-cell lymphoma (DLBCL), and less frequently Hodgkin lymphoma , the list of cases with more variable presentations in the literature is growing.
Patient Concerns: A 71-year-old Caucasian man initially consulted an otolaryngologist for a 1-year history of nasal congestion.
Aim: Evaluate a web-based tailored nursing intervention, TAVIE en m@rche, on increasing daily steps after an acute coronary syndrome.
Design: Parallel two-group multicentre randomized trial.
Methods: An experimental group receiving TAVIE en m@rche, was compared to a control group receiving hyperlinks to public websites.
Background: Instantaneous wave free ratio (iFR) does not require adenosine, but has a relatively wide intermediate range where functional assessment remains inconclusive. In this pilot study, we sought to enhance iFR through with the use of intracoronary (IC) saline (iFRs) and contrast media (iFRc) and determine whether these techniques correlated well with fractional flow reserve (FFR).
Methods: Patients with coronary artery stenosis (CAS) associated with an iFR in the intermediate zone (≥0.
Background: Despite the health benefits of increasing physical activity in the secondary prevention of acute coronary syndrome (ACS), up to 60% of ACS patients are insufficiently active. Evidence supporting the effect of Web-based interventions on increasing physical activity outcomes in ACS patients is growing. However, randomized controlled trials (RCTs) using Web-based technologies that measured objective physical activity outcomes are sparse.
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