Publications by authors named "D Cossu"
Autoimmune diseases represent a diverse array of disorders in which the immune system mistakenly attacks the body's own cells and tissues [...
View Article and Find Full Text PDFThis study aimed to explore the intricate relationship between mitochondrial dysfunction, infection, and neuroinflammation, focusing specifically on the impact of pathogenic epitopes of the Epstein-Barr Virus (EBV) nuclear antigen 1 (EBNA1) in a mouse model of mitochondrial dysfunctions. The investigation included female middle-aged and C57BL/6J wild-type mice immunized with EBNA1 or with active experimental autoimmune encephalomyelitis (EAE) induction by the myelin oligodendrocyte glycoprotein (MOG) peptide. The mice developed more severe EAE than the wild-type mice.
View Article and Find Full Text PDFSystemic rheumatic diseases, including conditions such as rheumatoid arthritis, Sjögren's syndrome, systemic sclerosis, and systemic lupus erythematosus, represent a complex array of autoimmune disorders characterized by chronic inflammation and diverse clinical manifestations. This study focuses on unraveling the genetic underpinnings of these diseases by examining polymorphisms in key genes related to their pathology. Utilizing a comprehensive genetic analysis, we have documented the involvement of these genetic variations in the pathogenesis of rheumatic diseases.
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- Multiple sclerosis (MS) is a serious inflammatory disease affecting the central nervous system, and a significant subgroup of patients with relapsing-remitting MS can transition to a more progressive form known as secondary progressive MS (SPMS).
- This study analyzed differences in the glymphatic system's function, a brain waste-clearing system, between patients with relapsing-remitting MS (RRMS) and SPMS using specialized MRI techniques.
- Results showed that the glymphatic function, measured by the ALPS index, was significantly lower in SPMS patients, indicating potential microstructural dysfunction in their brains compared to those with RRMS, despite minimal correlation with clinical measures of disease severity.
Multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocytes glycoprotein-antibody disease (MOGAD) are distinct autoimmune demyelinating disorders characterized by varying clinical and pathological characteristics. While the precise origins of these diseases remain elusive, a combination of genetic and environmental factors, including viral elements, have been suggested as potential contributors to their development. Our goal was to assess the occurrence of antibodies against pathogenic peptides associated with virus (EBV) and the human endogenous retrovirus-W (HERV-W) in serum samples obtained from Japanese individuals diagnosed with MS, NMOSD, and MOGAD and to make comparisons with a group of healthy controls (HCs).
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