Publications by authors named "D Coss"
A 72-year-old man presented with several months of weakness, poor appetite, and depressed moods. Laboratory tests indicated central hypocortisolism, hypothyroidism and hypogonadism, and mild hyperprolactinemia. Imaging indicated a homogenously enhancing solid suprasellar mass inseparable from the hypothalamus and contiguous with a thickened proximal infundibulum.
View Article and Find Full Text PDFPurpose: Molecular mechanisms involved in the pathogenesis and tumor progression of pituitary adenomas (PA) remain incompletely understood. Corticotroph and somatotroph PA are associated with a high clinical burden, and despite improved surgical outcomes and medical treatment options, they sometimes require multiple surgeries and radiation. Preliminary data suggested a role for O-GlcNAc Transferase (OGT), the enzyme responsible for the O-GlcNAcylation of proteins.
View Article and Find Full Text PDFArticle Synopsis
- Obesity in males is linked to hypogonadism, causing lower testosterone levels and sperm counts due to disruptions in brain circuits that manage reproduction, particularly affecting gonadotropin-releasing hormone (GnRH) neurons.
- Research using mice on a high-fat diet showed reduced luteinizing hormone (LH) levels and lower LH secretion frequency, while the pituitary response to GnRH remained unchanged.
- The study found that kisspeptin neurons, which are vital for regulating LH, are suppressed in obese mice, leading to lower receptor levels that affect kisspeptin synchronization, ultimately contributing to hypogonadism.
Background And Objectives: This study identified a clinically significant subset of patients with glioma with tumor outside of contrast enhancement present at autopsy and subsequently developed a method for detecting nonenhancing tumor using radio-pathomic mapping. We tested the hypothesis that autopsy-based radio-pathomic tumor probability maps would be able to noninvasively identify areas of infiltrative tumor beyond traditional imaging signatures.
Methods: A total of 159 tissue samples from 65 subjects were aligned to MRI acquired nearest to death for this retrospective study.