Publications by authors named "D Cornacchia"
Article Synopsis
- Aging is a significant risk factor for Alzheimer's disease, and researchers conducted a whole-genome CRISPR screen to find out how neuronal age is regulated.
- They discovered that the neddylation pathway affects both cellular aging and neurodegeneration related to Alzheimer's in human stem cells.
- Blocking neddylation led to more signs of aging and neuron loss, suggesting that targeting this pathway could be a new strategy to slow down Alzheimer's progression.
The differentiation of human pluripotent stem cells (hPSCs) provides access to most cell types and tissues. However, hPSC-derived lineages capture a fetal-stage of development and methods to accelerate progression to an aged identity are limited. Understanding the factors driving cellular age and rejuvenation is also essential for efforts aimed at extending human life and health span.
View Article and Find Full Text PDFThe biological function and disease association of human endogenous retroviruses (HERVs) are largely elusive. HERV-K(HML-2) has been associated with neurotoxicity, but there is no clear understanding of its role or mechanistic basis. We addressed the physiological functions of HERV-K(HML-2) in neuronal differentiation using CRISPR engineering to activate or repress its expression levels in a human-pluripotent-stem-cell-based system.
View Article and Find Full Text PDFBackground: Blood transfusion is a relevant issue for elderly and frail patients, as they are often anaemic and have chronic diseases. Transfusion of red blood cells (RBC) can potentially affect morbidity and mortality of elderly patients undergoing major orthopaedic surgery.
Materials And Methods: We carried out a retrospective analysis of 2,593 patients undergoing major orthopaedic surgery between 2013 and 2017 in a single research institution in the Region of Apulia.