Publications by authors named "D Corey Noyes"
Article Synopsis
- Regulatory T cells (Tregs) in solid tumors are linked to poor patient outcomes and contribute to dysfunction in tumor-infiltrating CD8 +T cells by causing an "exhaustion-like" state.
- The study found that reducing Treg levels can reverse the dysfunction in CD8 +T cells, with a notable link to CTLA-4 expression by Tregs.
- Analysis showed that as tumors progressed, there was a decrease in the diversity of CD8 +T cell clones and reduced IL-2 levels, indicating that Treg accumulation reshapes the T cell repertoire and negatively impacts survival.
The clinical utility of histone/protein deacetylase (HDAC) inhibitors in combinatorial regimens with proteasome inhibitors for patients with relapsed and refractory multiple myeloma (MM) is often limited by excessive toxicity due to HDAC inhibitor promiscuity with multiple HDACs. Therefore, more selective inhibition minimizing off-target toxicity may increase the clinical effectiveness of HDAC inhibitors. We demonstrated that plasma cell development and survival are dependent upon HDAC11, suggesting this enzyme is a promising therapeutic target in MM.
View Article and Find Full Text PDFAdoptive cell therapy using tumor-infiltrating lymphocytes (TILs) has shown activity in melanoma, but has not been previously evaluated in metastatic non-small cell lung cancer. We conducted a single-arm open-label phase 1 trial ( NCT03215810 ) of TILs administered with nivolumab in 20 patients with advanced non-small cell lung cancer following initial progression on nivolumab monotherapy. The primary end point was safety and secondary end points included objective response rate, duration of response and T cell persistence.
View Article and Find Full Text PDFPelvic and acetabular fracture care in England: current workload and future directions.
Ann R Coll Surg Engl
June 2021
Introduction: Fractures of the pelvis and acetabulum (PAFs) are challenging injuries, requiring specialist surgical input. Since implementation of the major trauma network in England in 2012, little has been published regarding the available services, workforce organisation and burden of PAF workload. The aim of this study was to assess the recent trends in volume of PAF workload, evaluate the provision of specialist care, and identify variation in available resources, staffing and training opportunity.
View Article and Find Full Text PDFArticle Synopsis
- Immunotherapy (IT) combined with targeted therapy (TT) can treat melanoma, but their combination often leads to toxicity; the study explores whether a specific treatment order (IT followed by TT) is beneficial.
- Mouse models with different types of mutant melanomas were treated with IT, TT, or the IT→TT sequence to assess tumor response and immune changes.
- Results showed that the IT→TT sequence enhanced T-cell infiltration, altered the immune environment, and improved therapeutic outcomes by preventing tumor evasion, highlighting that initial IT can enhance the effectiveness of subsequent TT.