Publications by authors named "D Corallo"
Article Synopsis
- Macrophages play a crucial role in the immune response within the tumor environment of colorectal cancer (CRC), and their unique properties can be harnessed to create targeted nanoparticles for treatment.
- Lipid nanovesicles (LNVs) were developed using membrane proteins from differentiated THP-1 cells, resulting in two types: T-LNVs and M1-LNVs, both loaded with the cancer drug doxorubicin (DOXO).
- M1-LNVs demonstrated greater effectiveness in targeting and killing cancer cells compared to T-LNVs, showing promise for precision medicine in cancer therapy with reduced side effects.
Microglia, the brain-resident immune cells, orchestrate neuroinflammatory responses and are crucial in the progression of neurological diseases, including ischemic stroke (IS), which accounts for approximately 85% of all strokes worldwide. Initially deemed detrimental, microglial activation has been shown to perform protective functions in the ischemic brain. Besides their effects on neurons, microglia play a role in promoting post-ischemic angiogenesis, a pivotal step for restoring oxygen and nutrient supply.
View Article and Find Full Text PDFNeuroblastoma (NB) is the most commonly diagnosed extracranial solid tumor in children, accounting for 15% of all childhood cancer deaths. Although the 5-year survival rate of patients with a high-risk disease has increased in recent decades, NB remains a challenge in pediatric oncology, and the identification of novel potential therapeutic targets and agents is an urgent clinical need. The RNA-binding protein LIN28B has been identified as an oncogene in NB and is associated with a poor prognosis.
View Article and Find Full Text PDFThe RNA-binding protein LIN28B, identified as an independent risk factor in high-risk neuroblastoma patients, is implicated in adverse treatment outcomes linked to metastasis and chemoresistance. Despite its clinical significance, the impact of LIN28B on neuroblastoma cell metabolism remains unexplored. This study employs a multi-omics approach, integrating transcriptome and metabolome data, to elucidate the global metabolic program associated with varying LIN28B expression levels over time.
View Article and Find Full Text PDFArticle Synopsis
- Metastatic models are anticipated to revolutionize preclinical screening for small-molecule drugs and biologics by creating more realistic testing environments that replicate 3D metastatic diseases.
- The study developed a 3D β-tricalcium phosphate (β-TCP) model for neuroblastoma bone metastasis, using advanced printing techniques to encourage cell growth in a supportive network, which was monitored using two-photon microscopy.
- Results showed that conventional chemotherapies required higher doses in 3D cultures to achieve the desired effects on tumor cells, emphasizing the necessity of 3D environments for accurate drug efficacy assessments and establishing β-TCP scaffolds as valuable tools in early drug discovery.