Publications by authors named "D Constantin-Teodosiu"
Insulin resistance is a risk factor for type 2 diabetes, and exercise can improve insulin sensitivity. However, following exercise, high circulating fatty acid (FA) levels might counteract this. We hypothesized that such inhibition would be reduced by forcibly increasing carbohydrate oxidation through pharmacological activation of the pyruvate dehydrogenase complex (PDC).
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- * Results showed a significant decline in insulin-stimulated leg glucose uptake and leg muscle volume after bed-rest, along with reduced myofibrillar protein synthesis and decreased muscle glycogen storage.
- * After reintroducing exercise (short-term exercise-supplemented remobilization), the study aimed to assess potential improvements in muscle volume, protein turnover, and glucose uptake, but the effects of this remobilization were not detailed.
Background: Bed rest (BR) reduces whole-body insulin-stimulated glucose disposal (GD) and alters muscle fuel metabolism, but little is known about metabolic adaptation from acute to chronic BR nor the mechanisms involved, particularly when volunteers are maintained in energy balance.
Methods: Healthy males (n = 10, 24.0 ± 1.