Publications by authors named "D Colon"
EMC1 is part of the endoplasmic reticulum (ER) membrane protein complex, whose functions include the insertion of transmembrane proteins into the ER membrane, ER-mitochondria contact, and lipid exchange. Here, we show that the gene is expressed in the somatic musculature and the protein localizes to the sarcoplasmic reticulum (SR) network. Muscle-specific RNAi led to severe motility defects and partial late pupae/early adulthood lethality, phenotypes that are rescued by co-expression with an transgene.
View Article and Find Full Text PDFArticle Synopsis
- After surviving sepsis, adults often have weakened immune systems and more chances of getting sick again, but it's unclear how this happens in kids.
- The study looked at different aged mice (2-week-old vs 6-week-old) to see how their immune systems responded after sepsis and found that younger mice were better at fighting off infections.
- The research suggests that older mice had higher levels of a substance called IL-33, which affects immune cells, while younger mice's immune systems reacted differently, showing that age impacts how sepsis affects patients.
The article discusses the impact of the digitalisation of politics on the place of bodies in the political and social life of liberal democracies. The author intends to show that the promise of the disappearance of bodies from the public space has only been partially fulfilled, and that ’surveillance capitalism’ has instead given new vigour to new forms of mobilisation characterised by the instrumentation of bodies for political purposes.
View Article and Find Full Text PDFIndividualizing the Throwing Progression Following Injury in Baseball Pitchers: the Past, Present, and Future.
Curr Rev Musculoskelet Med
December 2022
Purpose Of Review: A critical component of any rehabilitation program following injury is a graduated exposure of pathologic or vulnerable tissue to sport-specific stressors. A foundational aspect in the return to sport process following an injury in baseball athletes is the development of an interval throwing program. A shift has occurred in recent years from generic programs to individualized progressions.
View Article and Find Full Text PDFBackground: Neutrophil extracellular traps (NETs) are a recently discovered neutrophil defense mechanism which modulates several inflammatory conditions contributing to metabolic profile alterations. Therefore, the present study aimed to evaluate the production of NETs in obese patients and mice, verifying the possible mechanisms associated with the release of NETs by the adipose tissue.
Methods And Results: The present study investigated NETs production in human adipose tissue and also showing the neutrophils using intravital microscopy in mouse epididymal adipose tissue.