Publications by authors named "D Colombo"
Background: Cryptogenic organizing pneumonia (COP) is an interstitial lung disease, with causes including anti-CD20 antibodies. Ocrelizumab is a humanized monoclonal antibody against CD20 approved for use in relapsing-remitting or primary progressive multiple sclerosis (MS), with no conclusive data regarding pulmonary toxicity.
Cases: We describe two cases of COP associated with ocrelizumab use in multiple sclerosis patients.
Article Synopsis
- A reversal of timing between early diastolic velocity (e') and mitral inflow (E) occurs with high left atrial pressure, but its potential application for assessing right atrial pressure has not been studied previously.
- In a study comparing patients with pre-capillary pulmonary hypertension to healthy volunteers, it was found that the interval (T) is prolonged in those with pulmonary hypertension.
- Strong correlations between T and measured right atrial pressure, along with a high predictive value for identifying elevated pressures, suggest T could be a valuable tool in understanding the cardiac function in pulmonary hypertension.
Technological advances in high-throughput technologies improve our ability to explore the molecular mechanisms of life. Computational infrastructures for scientific applications fulfil a critical role in harnessing this potential. However, there is an ongoing need to improve accessibility and implement robust data security technologies to allow the processing of sensitive data, particularly human genetic data.
View Article and Find Full Text PDFGonadotropin-releasing hormone (GnRH) is the main regulator of the reproductive system, acting on gonadotropic cells by binding to the GnRH1 receptor (GnRH1R). Traditionally, therapies targeting this receptor have relied on peptide modulators, which required subcutaneous or intramuscular injections. Due to the limitations of the parenteral administrations, there is a growing interest in developing oral small molecule modulators of GnRH1R as more convenient therapeutic alternatives.
View Article and Find Full Text PDFArticle Synopsis
- - The study aimed to evaluate the accuracy of first responders in applying the START triage protocol during simulated mass casualty incidents and to identify factors influencing their performance and triage times.
- - Out of 1,090 simulated casualties, 83.6% were accurately triaged, with specific factors like heart rate and injury severity influencing overtriage, while factors like blood pressure were linked to undertriage.
- - The analysis also found that triage codes and the experience level of responders were significant in determining how quickly they could exit the scene after triaging patients.