Publications by authors named "D Colaizzo"
Background: Oral anticoagulants (OAC) may exacerbate menstrual bleeding in women of childbearing age; however, the existing literature on this issue has several limitations.
Materials And Methods: This study investigates abnormal uterine bleeding in women of childbearing age taking OAC-vitamin K antagonists or direct oral anticoagulants-for venous thromboembolism through a retrospective analysis of prospectively collected data. Uterine bleeding was assessed using the Pictorial Blood Assessment Chart (PBAC) and hemoglobin (Hb) values during anticoagulation compared with prior therapy.
Article Synopsis
- Gene-gene interactions are believed to play a significant role in the development of multifactorial diseases like cerebral venous thrombosis (CVT), highlighting potential causes of unexplained heritability.
- A study involving 882 CVT patients and 1,205 control participants found that specific gene variants significantly increased the likelihood of developing CVT, particularly when individuals had certain blood types.
- The research concluded that the interactions between specific genes could raise the risk of CVT by as much as 14 times, underscoring the importance of understanding these genetic factors in disease etiology.
Article Synopsis
- - The study investigates how age, sex, and imaging features relate to coma in patients with cerebral venous thrombosis (CVT), using data from a large international study.
- - Among 596 adult CVT patients, 8.9% experienced coma, with a higher prevalence in men (13.1%) compared to women (7.5%), despite CVT being more common in women.
- - Findings suggest that male sex and older age are significant factors linked to coma in CVT cases, highlighting a complex interplay between gender and clinical outcomes.
Article Synopsis
- Women of childbearing age face a venous thromboembolism (VTE) risk due to pregnancy and oral contraceptive use, with the impact of risk factors still uncertain.
- The study analyzed 532 women to identify how various risk factors influenced VTE associated with pregnancy and combined oral contraceptives, revealing no significant differences in complications between groups.
- Findings indicated that a family history of VTE significantly increases the risk of both COC- and pregnancy-associated VTE, while older age and smoking are also notable risk factors in these contexts.
Article Synopsis
- Cerebral venous thrombosis (CVT) is a rare type of stroke primarily affecting young adults, and this study investigates how age and gender, along with specific risk factors, influence its onset.
- Data were collected from a large, international study (BEAST) involving 1,309 CVT patients, revealing that the average age at onset for women is significantly younger (37 years) than for men (46 years).
- Findings indicate that women with risk factors like pregnancy or oral contraceptive use experience CVT much earlier, sometimes up to 12 years before men, highlighting the critical role of gender in CVT onset.