The Role of Beta-Hydroxybutyrate in Mitigating the Inflammatory and Metabolic Consequences of Uric Acid.

Uric acid (UA), a metabolite of purine and fructose metabolism, is linked to inflammation and metabolic disorders, including gout and cardiovascular disease. Its pro-inflammatory effects are largely driven by the activation of the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, leading to increased cytokine production. Beta-hydroxybutyrate (BHB), a ketone produced during fasting or carbohydrate restriction, has been shown to reduce inflammation.

Temporal RAGE Over-Expression Disrupts Lung Development by Modulating Apoptotic Signaling.

Receptors for advanced glycation end products (RAGE) are multiligand cell surface receptors found most abundantly in lung tissue. This study sought to evaluate the role of RAGE in lung development by using a transgenic (TG) mouse model that spatially and temporally controlled RAGE overexpression. Histological imaging revealed that RAGE upregulation from embryonic day (E) 15.

Practice variability in uptake and implementation of new US DHHS guidelines for feeding of HIV exposed infants.

New US guidelines support shared decision making regarding breastfeeding for mothers living with HIV and their neonates. We surveyed Pediatric Infectious Diseases Society members about implementation of these guidelines. We found heterogeneity in uptake, variability in clinical practice, and concerns about implementation.

Histone H3 tail modifications required for meiosis in .

Histone tail phosphorylation has diverse effects on a myriad of cellular processes, including cell division, and is highly conserved throughout eukaryotes. Histone H3 phosphorylation at threonine 3 (H3T3) during mitosis occurs at the inner centromeres and is required for proper biorientation of chromosomes on the mitotic spindle. While H3T3 is also phosphorylated during meiosis, a possible role for this modification has not been tested.

A PubMed search filter for efficiently retrieving exercise training studies.

Background: A barrier to evidence-informed exercise programming is locating studies of exercise training programs. The purpose of this study was to create a search filter for studies of exercise training programs for the PubMed electronic bibliographic database.

Methods: Candidate search terms were identified from three sources: exercise-relevant MeSH terms and their corresponding Entry terms, word frequency analysis of articles in a gold-standard reference set curated from systematic reviews focused on exercise training, and retrospective searching of articles retrieved in the search filter development and testing steps.