Publications by authors named "D Cirasola"
Postnatal human cytomegalovirus (HCMV) infection in newborns is well characterized for preterm infants but less so for term infants. We sought to analyze the rates and routes of HCMV transmission in full-term infants during the first year of life. A cohort of 120 HCMV seropositive mothers and their 122 newborns were tested after delivery for HCMV-DNA shedding in different bodily fluids.
View Article and Find Full Text PDFObjectives: Human cytomegalovirus (HCMV) non-primary infections can occur in pregnant women and may result in congenital infection. Comprehensive studies investigating the frequency, characteristics, risk factors and immune response of non-primary infection in pregnancy are missing, while the rate of vertical transmission is not known.
Methods: HCMV non-primary infection was investigated prospectively in 250 pregnant women.
Article Synopsis
- Strain-specific antibodies to HCMV glycoproteins B and H may help diagnose reinfections, leading to a study of IgG responses alongside viral genotyping.
- The study involved 45 subjects with either primary or non-primary HCMV infection, using real-time PCR and whole genome sequencing to identify the gB and gH genotypes, while measuring antibody responses through ELISA.
- Results showed that most subjects with primary infections had genotype-specific IgG antibodies for gB and gH, but nearly half of the primary infection subjects lacked gB-specific antibodies, indicating room for improvement in using this method for identifying reinfections.
Acetylcholine modulates the virulence of and regulates an appropriate immune response to infection in a infection model. Indeed, the evidence suggests that possesses a functional cholinergic receptor that can regulate filamentous growth and biofilm formation. Furthermore, immune cell subsets possess repertories of cholinergic receptors which regulate an effective and appropriate cellular immune response to infection.
View Article and Find Full Text PDFThe Candida parapsilosis group encompasses three species: C. parapsilosis, C. orthopsilosis, and C.
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