Publications by authors named "D Chuter"
Article Synopsis
- The FDA's Project Optimus is encouraging the use of Patient-reported Outcome (PRO) data to better assess how tolerable new cancer therapies are in early clinical trials, moving beyond just clinician evaluations of side effects.
- A virtual session engaged various experts and patient advocates to discuss how to effectively incorporate PROs in trial designs, highlighting the value of patient input in this process.
- While there is support for using PROs, participants expressed concerns that it might lead to lower recommended doses and hesitation among patients to accurately report symptom severity.
Article Synopsis
- Patient involvement in clinical cancer research has increased significantly, showing positive outcomes but lacking clear evidence on best practices.
- A literature review identified 58 key elements for successful patient involvement in oncology trials, emphasizing roles, diversity, and continuous engagement.
- The findings offer practical recommendations for researchers to effectively involve patients throughout all stages of clinical trial research.
PEARLS is a multi-stage randomised controlled trial for prostate cancer patients with pelvic and/or para-aortic PSMA-avid lymph node disease at presentation. The aim of the trial is to determine whether extending the radiotherapy field to cover the para-aortic lymph nodes (up to L1/L2 vertebral interspace) can improve outcomes for this patient group.
View Article and Find Full Text PDFNutritional intervention is an essential part of cancer treatments. Research and clinical evidence in cancer have shown that nutritional support can reduce length of hospitalisation, diminish treatment-related toxicity, and improve nutrient intake, quality of life, and physical function. Nutritional intervention can improve outcomes and help patients in the successful completion of oncological treatments by preventing malnutrition.
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