Solid-state self carbo-passivation for refurbishing colloidal dispersity of catalytic silica nanoreactors.

Silica-based nanostructures are among the most utilized materials. However, a persistent challenge is their irreversible agglomeration upon drying and heat treatments, restricting their homogeneous colloidal re-dispersion - a mandatory requirement for diverse bio-applications. We address this bottleneck by developing a self carbo-passivation (SCP) strategy: silica nanoparticles (NPs), pre-included with the catalytic metal precursors and organosilanes undergo thermochemical conversion with highly controlled interior-to-surface segregation of nanometer-scale "carbonaceous skin patches".

Flt3L enhances clonal diversification and selective expansion of intratumoral CD8 T cells while differentiating into effector-like cells.

PD-1 blockade enhances anti-tumoral CD8 T cell responses via type 1 conventional dendritic cells (cDC1s), but how cDC1s change the properties of intratumoral CD8 T cells remains to be determined. Here, we identified two populations of intratumoral CD8 T cells distinguished by their expression of asialo-ganglio-N-tetraosylceramide (asGM1). asGM1 and asGM1CD8 T cells show enriched expression of genes characteristic for precursor exhausted T (Tpex) cells and terminally exhausted T (Tex) cells, respectively.

Rational corticosteroids administration and antibiotic treatment is key to managing cutaneous anthrax.

Background: Anthrax is a global health concern, with cutaneous anthrax accounting for over 95% of cases and generally promising outcomes. Nonetheless, the absence of timely intervention can result in mortality rates of 10-40%. This research aims to explore the clinical presentations and phenotypic characteristics of cutaneous anthrax patients and evaluate the efficacy of various therapeutic approaches.

Big data-based reference centiles for body composition in Korean children and adolescents: a cross-sectional study.

Background: The changes in body composition during puberty not only contribute to the differences in body composition between adult males and females but also have associations with growth problems and metabolic disorders, including obesity. Therefore, understanding the changes in body composition during the pubertal period and analyzing reference values based on race and gender are essential research resources. The objective of this study was to generate reference centiles for body composition on a monthly basis using an extensive dataset of body composition information from Korean children and adolescents.