The Impact of Systemic Health Parameters on Intraocular Pressure in the Western Region of Saudi Arabia.

Background A normal intraocular pressure (IOP) is essential for maintaining the normal structure and function of the eyes. Furthermore, an elevated IOP is a known risk factor for glaucoma. As the results from studies addressing the relationship between IOP and systemic health parameters are conflicting, researchers have not reached a consensus.

Intravenous lidocaine for the emergency department treatment of acute radicular low back pain, a randomized controlled trial.

Background: Acute radicular back pain is a frequent complaint of patients presenting to the Emergency Department.

Study Objective: Determine the efficacy of intravenous lidocaine when compared to ketorolac for the treatment of acute radicular low back pain.

Methods: Randomized double-blind study of 41 patients aged 18-55 years presenting with acute radicular low back pain.

Attention-deficit/hyperactivity disorder genomics: update for clinicians.

Attention deficit, hyperactivity disorder (ADHD) is familial and highly heritable. Several candidate genes involved in neurotransmission have been identified, however these confer minimal risk, suggesting that for the most part, ADHD is not caused by single common genetic variants. Advances in genotyping enabling investigation at the level of the genome have led to the discovery of rare structural variants suggesting that ADHD is a genomic disorder, with potentially thousands of variants, and common neuronal pathways disrupted by numerous rare variants resulting in similar ADHD phenotypes.

Comparison of oral aspirin versus topical applied methyl salicylate for platelet inhibition.

Background: Oral acetylsalicylic acid (aspirin) is the primary antiplatelet therapy in the treatment of acute myocardial infarction and acute coronary syndrome. Methyl salicylate (MS; oil of wintergreen) is compounded into many over-the-counter antiinflammatory muscle preparations and has been shown to inhibit platelet aggregation locally and to be absorbed systemically.

Objective: To assess the ability of topically applied MS to inhibit systemic platelet aggregation for patients who are unable to tolerate oral drug therapy.

Fasciotomy worsens the amount of myonecrosis in a porcine model of crotaline envenomation.

Study Objective: We evaluate the efficacy of fasciotomy or crotaline snake antivenom in reducing myonecrosis.

Methods: We used a randomized, blinded, controlled acute animal preparation. Twenty anesthetized swine were injected intramuscularly in the anterior tibiales muscle of both hind limbs with 6 mg/kg of Crotalus atrox venom (total of 12 mg/kg of venom per animal).