Identification of antimalarial phytoconstituents from Tinospora sinensis (Lour.) Merr. Stem by in vitro whole cell assay and multiple targets directed in silico screening against Plasmodium falciparum.

Ethnopharmacological Relevance: Tinospora sinensis (Lour.) Merr., from the family Menispermaceae, is widely used in Indian folk and Ayurvedic medicine.

In Vivo and in Silico Based Evaluation of Antidiabetic Potential of an Isolated Flavonoid from Allium hookeri in Type 2 Diabetic Rat Model.

Allium hookeri (F: Liliaceae), an indigenous plant of Manipur, India, is traditionally used to treat various diseases and disorders like diabetes, hypertension, and stomach ache. In our previous study, the methanol extract of the plant showed significant antidiabetic potential in rats. In the present study, we evaluated the antidiabetic potential of a flavonoid compound named MEA isolated from the methanolic leaf extract of A.

and guided identification of antimalarial phytoconstituent(s) in the root of (Burm.) Merr.

As a part of our continuous effort to find new therapeutic agents from natural sources, the hydroalcoholic (1:1) extract of (Burm.) Merr. root was selected for the identification of possible antimalarial phytoconstituents.

Revelation of potential drug targets of luteolin in through multi-target molecular dynamics simulation studies.

techniques offer a fast, accurate, reliable, and economical approach to studying the molecular interactions between compounds and proteins. In this study, our main aim is to use techniques as a rational approach for the prediction of the molecular drug targets for luteolin against . Multi-target molecular docking, 100 nanoseconds (ns) molecular dynamics (MD) simulations, and Molecular Mechanics-Generalized Born Surface Area (MM-GBSA) binding free energy calculations were carried out for luteolin against dihydrofolate reductase thymidylate synthase (DHFR-TS), dihydroorotate dehydrogenase (DHODH), and falcipain-2.

Resilience and its relationship with disability in persons with bipolar disorder and schizophrenia: A comparative study.

Background: Resilience is the capacity to bounce back from adversity. Severe mental illnesses are associated with poor and heterogeneous functional outcomes. Symptom remission is inadequate to achieve patient-oriented outcome, and positive psychopathology constructs like resilience have emerged as possible mediators.