Publications by authors named "D Chatfield"
Article Synopsis
- Post-mortem studies reveal that patients who died from COVID-19 often show brainstem damage, which may result from immune responses during and after the infection.
- Symptoms such as fatigue, breathlessness, and chest pain in post-hospitalization COVID-19 patients may be linked to these brainstem abnormalities.
- Using advanced MRI techniques, a study found increased susceptibility in key brainstem regions of COVID-19 survivors, indicating a correlation between these changes and the severity of their illness and recovery outcomes.
Article Synopsis
- The study investigated the effectiveness of various harmonization methods (neuroCombat, longCombat, gamCombat) to address scanner effects in multi-center neuroimaging studies focused on both structural and diffusion MRI metrics.
- Using data from 73 healthy volunteers and 161 scans across different sites and MRI machines, the research analyzed metrics related to brain structure and diffusion.
- Results showed that while structural data did not benefit from harmonization due to minor scanner effects, diffusion data exhibited significant variance that was effectively harmonized, improving detection of genuine biological differences without inflating false positives.
Human coronavirus disease 2019 (COVID-19) due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has multiple neurological consequences, but its long-term effect on brain health is still uncertain. The cerebrovascular consequences of COVID-19 may also affect brain health. We studied the chronic effect of COVID-19 on cerebrovascular health, in relation to acute severity, adverse clinical outcomes and in contrast to control group data.
View Article and Find Full Text PDFCOVID-19 is associated with neurological complications including stroke, delirium and encephalitis. Furthermore, a post-viral syndrome dominated by neuropsychiatric symptoms is common, and is seemingly unrelated to COVID-19 severity. The true frequency and underlying mechanisms of neurological injury are unknown, but exaggerated host inflammatory responses appear to be a key driver of COVID-19 severity.
View Article and Find Full Text PDFBackground: Preliminary evidence has highlighted a possible association between severe COVID-19 and persistent cognitive deficits. Further research is required to confirm this association, determine whether cognitive deficits relate to clinical features from the acute phase or to mental health status at the point of assessment, and quantify rate of recovery.
Methods: 46 individuals who received critical care for COVID-19 at Addenbrooke's hospital between 10th March 2020 and 31st July 2020 (16 mechanically ventilated) underwent detailed computerised cognitive assessment alongside scales measuring anxiety, depression and post-traumatic stress disorder under supervised conditions at a mean follow up of 6.