Publications by authors named "D Chaiwanichsiri"
In Thailand, platelet product from a blood donor was transfused to a recipient who had dengue. Two days later, the donor was confirmed to have monkeypox virus infection. Monkeypox virus DNA was undetectable in recipient specimens up to 2 weeks after transfusion.
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- - A rare Rh variant known as DEL phenotype can lead to anti-D alloimmunization in patients typed as D-negative (D-) who receive DEL red blood cells, highlighting limitations in routine blood typing.
- - A 17-year-old D- Thai male with immunodeficiency developed anti-D antibodies after multiple transfusions, prompting an investigation of the blood donors which revealed that many were actually DEL positive despite standard D- typing.
- - This case underscores the need for enhanced blood management policies in Thailand, advocating for molecular testing to correctly identify DEL phenotypes and prevent alloimmunization in D- patients.
Coronavirus disease 2019 (COVID-19) is a contagious illness worldwide. While guidelines for the treatment of COVID-19 have been established, the understanding of the relationship among neutralizing antibodies, cytokines, and the combined use of antiviral medications, steroid drugs, and convalescent plasma therapy remains limited. Here, we investigated the connection between the immunological response and the efficacy of convalescent plasma therapy in COVID-19 patients with moderate-to-severe pneumonia.
View Article and Find Full Text PDFBackground: Discriminating individuals with "Asian type DEL" from those who are "true D-negative" (D-) among serologically D- donors/patients in Asia would be very valuable, as clinical outcomes are different in these groups. Here we investigated the molecular basis of D-negativity in Thai blood donors, designing a specific strategy for this purpose.
Materials And Methods: After routine testing, a total of 1,270 serologically D- blood donors originating from Central, Northeastern and South Thailand underwent analysis of the RHD gene by (i) quantitative multiplex polymerase chain reaction of short fluorescent fragments (QMPSF); (ii) direct sequencing of exon 9 to identify the c.
Neutralizing antibody level is used to predict immune protection against SARS-CoV-2 infection. Spike protein of SARS-CoV-2 is a major target for virus-neutralizing antibody. A number of neutralizing epitopes were mapped on receptor binding domain (RBD) and N-terminal domain (NTD) of S1 subunit of the spike.
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