Plasma-Induced Graft Polymerization for the In Situ Synthesis of Cross-Linked Nanocoatings.

Conventional technology for the modification of surfaces loaded with nanomaterials typically requires a three-step process: (1) the construction of a polymer platform, (2) the synthesis of nanoparticles (NPs), and (3) the immobilization or anchoring of NPs. During the immobilization or anchoring process, there is an unavoidable excess of NPs primarily situated at the top of the surface, resulting in the agglomeration of aggregates. These aggregates can form different shapes and sizes, often creating an uneven distribution of NPs, resulting in an unstable coating that gradually releases NPs over time.

Metabolomic Prediction of Breast Cancer Treatment-Induced Neurologic and Metabolic Toxicities.

Purpose: Long-term treatment-related toxicities, such as neurologic and metabolic toxicities, are major issues in breast cancer. We investigated the interest of metabolomic profiling to predict toxicities.

Experimental Design: Untargeted high-resolution metabolomic profiles of 992 patients with estrogen receptor (ER)+/HER2- breast cancer from the prospective CANTO cohort were acquired (n = 1935 metabolites).

Modeling of Intracellular Taurine Levels Associated with Ovarian Cancer Reveals Activation of p53, ERK, mTOR and DNA-Damage-Sensing-Dependent Cell Protection.

Taurine, a non-proteogenic amino acid and commonly used nutritional supplement, can protect various tissues from degeneration associated with the action of the DNA-damaging chemotherapeutic agent cisplatin. Whether and how taurine protects human ovarian cancer (OC) cells from DNA damage caused by cisplatin is not well understood. We found that OC ascites-derived cells contained significantly more intracellular taurine than cell culture-modeled OC.

Application of Argon Plasma Technology for the Synthesis of Anti-Infective Copper Nanoparticles.

The synthesis of copper nanoparticles (CuNPs) was accomplished by using a rapid, green, and versatile argon plasma reduction method that involves solvent extraction. With this method, a plasma-solid state interaction forms and CuNPs can be synthesized from copper(II) sulfate using a low-pressure, low-temperature argon plasma. Characterization studies of the CuNPs revealed that when a metal precursor is treated under optimal experimental conditions of 80 W of argon plasma for 300 s, brown CuNPs are synthesized.