Publications by authors named "D Castle"
Background: The prenatal and early-life periods pose a crucial neurodevelopmental window whereby disruptions to the intestinal microbiota and the developing brain may have adverse impacts. As antibiotics affect the human intestinal microbiome, it follows that early-life antibiotic exposure may be associated with later-life psychiatric or neurocognitive outcomes.
Aims: To explore the association between early-life (in utero and early childhood (age 0-2 years)) antibiotic exposure and the subsequent risk of psychiatric and neurocognitive outcomes.
Background And Aims: Glutamate plays a crucial role in cognition, learning, and mood regulation, with studies suggesting glutamatergic dysfunction in chronic schizophrenia. This study explored glutamate levels in the occipital cortex (OCC) and cognitive function in ultra-treatment resistant schizophrenia (uTRS) compared to healthy controls.
Methods: Fifteen uTRS participants and 19 healthy controls underwent 3T proton magnetic resonance spectroscopy (H-MRS) to measure glutamate levels in the OCC.
Article Synopsis
- This systematic review aims to evaluate existing research on treatments for mental health, cognition, and psychological well-being in individuals experiencing long COVID.
- A total of 33 documents from 31 studies were analyzed, covering various interventions, including psychosocial, pharmaceutical, natural supplements, neurocognitive, physical rehabilitation, and integrated approaches.
- Although some randomized controlled trials showed promising results, the overall findings are inconclusive due to high variability among studies, risk of bias, and inadequate reporting, indicating a need for ongoing research and regular updates for stakeholders.
Article Synopsis
- "Revolving door patients" are people who keep going back to the hospital because they aren't getting better, often due to not taking their medicine or not having enough support.
- The idea of a Mobile Delivery Program (MDP) is proposed, where healthcare workers bring medicines and help directly to these patients' homes to make it easier for them to stick to their treatment.
- This program aims to help patients avoid going back to the hospital repeatedly, improve their overall health, and save a lot of money that is currently spent on hospital visits and other related costs.