Publications by authors named "D Carrizo Gallardo"
Unlabelled: Population aging has caused a rise in neurodegenerative diseases among which includes Parkinson's disease. However, in Chile, there is still little knowledge about how Parkinson's disease is associated with functionality in elderly people.
Aim: to examine the association between Parkinson's disease and functionality in elderly people of Maipú, Metropolitan region, between the years 2017-2019.
Article Synopsis
- Natural killer (NK) cells can detect and destroy malignant cells using specific receptors, and the study investigates how certain genetic variations in these receptors impact relapse and graft-versus-host disease (GVHD) after stem cell transplantation.
- Researchers analyzed 1,638 genetic variations in 21 non-KIR NK cell receptor genes among 1,491 donors from multiple countries to assess their effects on relapse and GVHD, identifying eleven relevant polymorphisms.
- Although some genetic variations showed potential links to NK cell activity in vitro, the overall findings did not demonstrate strong effects of these non-KIR NK cell receptors on HSCT outcomes, as associations were not confirmed in the replication cohort.
Background: Locally advanced cervical cancer is treated with chemoradiotherapy (standard of care), but many patients still relapse and die from metastatic disease. We investigated chemoradiotherapy with or without induction chemotherapy to determine whether induction chemotherapy improves both progression-free survival and overall survival.
Methods: The INTERLACE trial was a multicentre, randomised phase 3 trial done at 32 medical centres in Brazil, India, Italy, Mexico, and the UK.
Article Synopsis
- The text discusses a new long-term survival model that combines Poisson and Birnbaum-Saunders distributions to handle competing causes of events in survivability studies.
- It highlights statistical properties of the model, introduces an Expectation-Maximization algorithm for parameter estimation, and sets conditions for ensuring reliable statistical inference.
- The practical application is demonstrated using a breast cancer dataset from São Paulo, Brazil, showing that this new model offers better fitting than traditional models.
Lattice structures have become an innovative solution for the improvement of part design, as they are able to substitute solid regions, maintain mechanical capabilities, and reduce material usage; however, dimensional quality control of these geometries is challenging. X-ray computed tomography (XCT) is the most suitable non-destructive metrological technique as it is capable of characterizing internal features and hidden elements. Uncertainty estimation of XCT is still in development, and studies typically use high-resolution calibrated devices such as focal variation microscopes (FVMs) as a reference, focusing on certain parts of the lattice but not the whole structure.
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