Publications by authors named "D Carnevali"
Article Synopsis
- Cellular phenotypic heterogeneity is crucial in biological processes but understanding its origins is challenging, often influenced by chromatin structure changes due to factors like viral infections and cancer.* -
- Researchers developed an AI called AINU that uses deep learning to identify unique nuclear signatures at a nanoscale level, distinguishing various cell states from super-resolution microscopy images.* -
- AINU can accurately classify different human cells, including stem cells and infected or cancerous cells, and reveals that the location of RNA polymerase II helps differentiate between somatic and induced pluripotent stem cells, showing promise for improving diagnostics and therapies.*
Alu retrotransposons, which form the largest family of mobile DNA elements in the human genome, have recently come to attention as a potential source of regulatory novelties, most notably by participating in enhancer function. Even though Alu transcription by RNA polymerase III is subjected to tight epigenetic silencing, their expression has long been known to increase in response to various types of stress, including viral infection. Here we show that, in primary human fibroblasts, adenovirus small e1a triggered derepression of hundreds of individual Alus by promoting TFIIIB recruitment by Alu-bound TFIIIC.
View Article and Find Full Text PDFEmbryo size, specification, and homeostasis are regulated by a complex gene regulatory and signaling network. Here we used gene expression signatures of Wnt-activated mouse embryonic stem cell (mESC) clones to reverse engineer an mESC regulatory network. We identify NKX1-2 as a novel master regulator of preimplantation embryo development.
View Article and Find Full Text PDFPeople with autism and intellectual disabilities, much like individuals with typical development, share a fundamental right and aspiration to realise their own life projects. However, this natural pursuit is uniquely challenging for individuals with autism and intellectual disabilities due to their communication and adaptive hurdles. This growing need has prompted the development of a specific procedure for crafting life projects geared toward enhancing their quality of life.
View Article and Find Full Text PDFBackground: Preventing and reducing nosocomial infections is a public health goal. Concern about healthcare-associated fungal infections has increased in recent years due to the emergence and spread of new pathogens, increasing antifungal resistance and outbreaks in hospital settings.
Aim: To investigate the presence of medically relevant fungal species on environmental surfaces in 12 intensive care units of eight hospitals in Milan, Italy.