Publications by authors named "D Callanan"
Aims: Perineural invasion (PNI) is associated with survival in oral cavity squamous cell carcinoma (OCSCC). There is evidence to suggest that PNI location and extent may be of additional significance. The primary aim of this study was to evaluate the prognostic ability of PNI, including location and extent, in early-stage OCSCC.
View Article and Find Full Text PDFBackground: The prognostic significance of close margins in oral squamous cell carcinoma (OSCC) is controversial. We wished to investigate the impact of close margins on the risk of local recurrence (LR) in OSCC according to the oral subsite.
Methods: A retrospective cohort study of 342 OSCC patients undergoing primary surgical treatment was conducted.
Article Synopsis
- The alternative pathway of the complement system is linked to age-related macular degeneration (AMD), with current FDA-approved treatments showing potential risks that highlight the need for safer options.
- Researchers have found that Poly Sialic acid nanoparticles (PolySia-NP) can inhibit the alternative complement pathway and enhance the binding of complement factor H (CFH), potentially offering safer therapeutic benefits.
- PolySia-NP treatment not only suppresses harmful complement activity and inflammatory responses in various models but also reduces neovascularization, presenting a promising alternative to existing AMD treatments.
An inflammation-resolving polysialic acid-decorated PLGA nanoparticle (PolySia-NP) has been developed to treat geographic atrophy/age-related macular degeneration and other conditions caused by macrophage and complement over-activation. While PolySia-NPs have demonstrated pre-clinical efficacy, this study evaluated its systemic and intraocular safety. PolySia-NPs were evaluated in vitro for mutagenic activity using strains and , with and without metabolic activation; cytotoxicity was evaluated based on its interference with normal mitosis.
View Article and Find Full Text PDFBackground: There is an ongoing need to identify pathologic prognosticators in early-stage oral cavity squamous cell carcinoma (OCSCC) to aid selection of patients who may benefit from adjuvant treatment. The objective of this study was to evaluate the prognostic ability of worst pattern of invasion-5 (WPOI-5) defined by the presence of satellite nodules, extratumoural perineural invasion (PNI) and/or extratumoural lymphovascular space invasion (LVI) in low-stage, node negative OCSCC.
Methods: This was a retrospective study of 160 patients with T1/T2N0 tumours staged using TNM7 treated surgically.