The atomic force microscope (AFM), as it is able to characterize surface topography as well determine the AFM cantilever tip-surface force, proves effective at estimating the value of the Hamaker constant, , for a given solid material. Two main AFM-based methods have been proposed for estimating values of . In the approach-to-contact (AtC) method, Hamaker constants are inferred from the deflections at which the AFM tip first jumps into contact with the substrate.
View Article and Find Full Text PDFPorcine delta-coronavirus (PDCoV) spillovers were recently detected in febrile children, underscoring the recurrent zoonoses of divergent CoVs. To date, no vaccines or specific therapeutics are approved for use in humans against PDCoV. To prepare for possible future PDCoV epidemics, we isolated PDCoV spike (S)-directed monoclonal antibodies (mAbs) from humanized mice and found that two, designated PD33 and PD41, broadly neutralized a panel of PDCoV variants.
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