Publications by authors named "D C van Der Zee"
Repositioning maneuvers for benign paroxysmal positional vertigo (BPPV) designed to induce otoconial movement in one canal can trigger and sometimes unwittingly treat BPPV in other canals. Patients with BPPV are best managed by precisely diagnosing the canal variant and using correctly performed, standardized testing and treatment maneuvers.
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- In patients with unilateral vestibular loss (UVL), vibrations can trigger a response known as vibration-induced nystagmus (VIN), where eye movements are directed toward the affected ear due to imbalances in signals from the vestibular system.
- A study employed a neural network model to hypothesize that the brain could misinterpret head orientation during vibration, leading to additional "virtual" translational effects; this means the angle of the head relative to gravity would affect the VIN response.
- The research confirmed the hypothesis through experiments with three patients, showing the expected patterns of VIN based on head positions, indicating that VIN could help identify subtle vestibular imbalances when other signs are unclear.
Radiographic Horizontal Conjugate Gaze Deviation: Clinical Correlates.
Neurol Clin Pract
February 2025
Article Synopsis
- The review highlights the diagnostic significance of radiographic horizontal conjugate gaze deviation (Rad h-CGD) in identifying various neurologic and vestibular disorders, building on findings from 2003 by Simon et al.* -
- Different clinical correlates of Rad h-CGD were identified, showcasing how the angle of deviation can help localize lesions, while suggesting an algorithm for better interpretation based on past literature and clinical experience.* -
- Although Rad h-CGD is helpful in diagnosing and localizing issues, it cannot solely differentiate between types of lesions, emphasizing the importance of clinical context and noting potential overlaps with conditions like strokes and vestibular syndromes.*
Progressive supranuclear palsy (PSP) is a neurodegenerative disorder with an estimated prevalence of 5-7 people in 100,000. Clinically characterized by impairments in gait, balance, and eye movements, as well as aggregated Tau pathology, PSP leads to death in approximately 5-8 years. No disease-modifying treatments are currently available.
View Article and Find Full Text PDFBackground: The benefit of intravenous thrombolysis with alteplase before endovascular thrombectomy (EVT) for acute ischemic stroke due to large vessel occlusion remains debated. In this study, we analyzed the cost-effectiveness of EVT alone versus intravenous alteplase before EVT in patients directly admitted to EVT-capable stroke centers from the Dutch health care payer perspective.
Methods: A decision analysis was performed using a Markov model with 15-year simulated follow-up to estimate total costs, quality-adjusted life years, and an incremental cost-effectiveness ratio of intravenous alteplase before EVT compared with EVT alone.