Yes-associated protein-based detection of acute type A aortic dissection and evaluation of therapeutic responses.

Background: Acute aortic dissection is a lethal cardiovascular emergency; early diagnosis is critically necessary. Novel serum biomarkers can potentially help in early detection and estimation of postoperative outcomes. Yes-associated protein (YAP) is a critical effector of the Hippo pathway, our aim was to explore the association between YAP and the diagnosis and prognosis of AD.

Vascular endothelial growth factor-D improves lung vascular integrity during acute lung injury.

Disorders in pulmonary vascular integrity are a prominent feature in many lung diseases. Paracrine signaling is highly enriched in the lung and plays a crucial role in regulating vascular homeostasis. However, the specific local cell-cell crosstalk signals that maintain pulmonary microvascular stability in adult animals and humans remain largely unexplored.

The impact of ferroptosis and ferroptosis-related non-coding RNAs on breast cancer progression.

Ferroptosis, distinct from apoptosis, is primarily characterized by the accumulation of iron-dependent lipid peroxides (LPO) and reactive oxygen species (ROS). This process plays a pivotal role in the pathophysiology of various diseases and has recently emerged as a promising therapeutic strategy in oncology, garnering significant attention. Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), serve as crucial regulators in numerous biological processes, particularly in cancer initiation and progression.

Development and assessment of the health-related quality of life scale for children with hearing loss in China.

Background: Hearing loss significantly affects children's lives; however, the health-related quality of life (QoL) of children with this disability is not well measured. We sought to develop a reliable and valid measure of health-related QoL in children with hearing loss.

Methods: We constructed a conceptual framework to assess the QoL of children with hearing loss based on the Pediatric Quality of Life Inventory™ Version 4.

Low-threshold surface-emitting colloidal quantum-dot circular Bragg laser array.

Colloidal quantum dots (CQDs) are attractive gain media due to their wavelength-tunability and low optical gain threshold. Consequently, CQD lasers, especially the surface-emitting ones, are promising candidates for display, sensing and communication. However, it remains challenging to achieve a low-threshold surface-emitting CQD laser array with high stability and integration density.