Publications by authors named "D C Rigiracciolo"
Advances in bladder cancer (BCa) treatment have been hampered by the lack of predictive biomarkers and targeted therapies. Here, we demonstrate that loss of the tumor suppressor NUMB promotes aggressive bladder tumorigenesis and worsens disease outcomes. Retrospective cohort studies show that NUMB-loss correlates with poor prognosis in post-cystectomy muscle-invasive BCa patients and increased risk of muscle invasion progression in non-muscle invasive BCa patients.
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- - Uveal melanoma (UM) is the most common eye cancer in adults, primarily caused by mutations in GNAQ/GNA11, but current treatment options are limited, especially for metastatic cases (mUM).
- - A drug screen comparing GNAQ-mutant UM with BRAF-mutant skin melanoma identified darovasertib as the most effective compound for UM, inhibiting specific kinases involved in signaling pathways that drive UM growth.
- - Darovasertib works well with FAK inhibitors, showing promise in stopping UM growth and inducing cell death in laboratory tests and mouse models, highlighting a potential new treatment strategy for mUM.
The G protein-coupled estrogen receptor (GPER) mediates estrogen action in different pathophysiological conditions, including cancer. GPER expression and signaling have been found to join in the progression of triple-negative breast cancer (TNBC), even though controversial data have been reported. In present study, we aimed at providing new mechanistic and biological discoveries knocking out (KO) GPER expression by CRISPR/Cas9 technology in MDA-MB-231 TNBC cells.
View Article and Find Full Text PDFThe receptor for advanced glycation end products (RAGE) is implicated in diabetes and obesity complications, as well as in breast cancer (BC). Herein, we evaluated whether RAGE contributes to the oncogenic actions of Insulin, which plays a key role in BC progression particularly in obese and diabetic patients. Analysis of the publicly available METABRIC study, which collects gene expression and clinical data from a large cohort (n = 1904) of BC patients, revealed that RAGE and the Insulin Receptor (IR) are co-expressed and associated with negative prognostic parameters.
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