Publications by authors named "D C Plummer"
Broad heterogeneity in pancreatic β-cell function and morphology has been widely reported. However, determining which components of this cellular heterogeneity serve a diabetes-relevant function remains challenging. Here, we integrate single-cell transcriptome, single-nuclei chromatin accessibility, and cell-type specific 3D genome profiles from human islets and identify Type II Diabetes (T2D)-associated β-cell heterogeneity at both transcriptomic and epigenomic levels.
View Article and Find Full Text PDFBackground: There are well-documented disparities in rates of continued breastfeeding. Existing research regarding breastfeeding during COVID-19 has raised concerns that the pandemic may have exacerbated these disparities.
Research Aims: The aim of this research was first to quantify disparities in any breastfeeding associated with the maternal factors of race/ethnicity, age, insurance payor, and zip code rates of education in North Carolina.
Water vapor plays an important role in many aspects of the climate system, by affecting radiation, cloud formation, atmospheric chemistry and dynamics. Even the low stratospheric water vapor content provides an important climate feedback, but current climate models show a substantial moist bias in the lowermost stratosphere. Here we report crucial sensitivity of the atmospheric circulation in the stratosphere and troposphere to the abundance of water vapor in the lowermost stratosphere.
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- UV light mainly causes C > T mutations in certain DNA sequences, but melanoma driver mutations often involve different changes like T > A, T > C, and C > A, which are not well understood in relation to UV exposure.
- Through experiments with yeast exposed to UVB and UVA light, researchers found that UVB mainly induces C > T, T > C, and T > A mutations, while UVA results in fewer mutations with a distinct pattern predominantly featuring C > A/G > T substitutions linked to oxidative damage.
- The study suggests that both UVB and UVA exposure can contribute to the noncanonical mutations associated with melanoma, with specific mechanisms and patterns underlying the mutations arising from each type of UV light.
UV exposure induces a mutation signature of C > T substitutions at dipyrimidines in skin cancers. We recently identified additional UV-induced AC > TT and A > T substitutions that could respectively cause BRAF V600K and V600E oncogenic mutations. The mutagenic bypass mechanism past these atypical lesions, however, is unknown.
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