Ternary complex components responsible for rapid LDL internalization as biomarkers for breast cancer associated with proliferation and early recurrence.

The ternary complex of PGRMC1-σ2R/TMEM97-LDLR has recently been discovered and plays a role in cholesterol transport. This study investigated whether individual components of that complex are prognostic breast cancer biomarkers and defined expression in established molecular subtypes. 4,463 invasive breast cancers were analyzed as a function of molecular and phenotypic markers, estimates of cellular proliferation, and recurrence-free survival.

Identifying novel response markers for spinal muscular atrophy revealed by targeted proteomics following gene therapy.

Spinal muscular atrophy (SMA) is a progressive disease that affects motor neurons, with symptoms usually starting in infancy or early childhood. Recent breakthroughs in treatments targeting SMA have improved both lifespan and quality of life for infants and children with the disease. Given the impact of these treatments, it is essential to develop methods for managing treatment-induced changes in disease characteristics.

Effect of plasma-activated water on chlorophyll retention in detached Tejpat () leaves.

In this work, the atmospheric pressure air gliding arc discharge has been produced for the generation of plasma-activated water (PAW) and studying its effect on the chlorophyll retention and greenness of Tejpat () leaves. The discharge is characterized via electrical and optical methods to calculate the electron excitation temperature (1.38 eV) and density ( cm) of the plasma.

Ability of clinical data to predict readmission in Child and Adolescent Mental Health Services.

This study addresses the challenge of predicting readmissions in Child and Adolescent Mental Health Services (CAMHS) by analyzing the predictability of readmissions over short, medium, and long term periods. Using health records spanning 35 years, which included 22,643 patients and 30,938 episodes of care, we focused on the episode of care as a central unit, defined as a referral-discharge cycle that incorporates assessments and interventions. Data pre-processing involved handling missing values, normalizing, and transforming data, while resolving issues related to overlapping episodes and correcting registration errors where possible.

Microbial electrosynthesis technology for CO mitigation, biomethane production, and ex-situ biogas upgrading.

Currently, global annual CO emissions from fossil fuel consumption are extremely high, surpassing tens of billions of tons, yet our capacity to capture and utilize CO remains below a small fraction of the amount generated. Microbial electrosynthesis (MES) systems, an integration of microbial metabolism with electrochemistry, have emerged as a highly efficient and promising bio-based carbon-capture-and-utilization technology over other conventional techniques. MES is a unique technology for lowering the atmospheric CO as well as CO in the biogas, and also simultaneously convert them to renewable bioenergy, such as biomethane.