Publications by authors named "D C McGiffin"
Background: Bypass graft surgery is a key surgical intervention for ischemic heart disease (coronary bypass graft surgery) and critical limb ischemia (peripheral bypass graft surgery). Graft occlusion remains a significant clinical problem for both types. Further research into the pathobiological mechanisms of graft occlusion are needed in order to design targeted therapeutic strategies.
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- - Open-lung ventilation during cardiopulmonary bypass (CPB) may help reduce postoperative lung damage in heart transplant patients, based on a study using sheep models to compare ventilatory strategies during surgery.
- - The study found that the group receiving open-lung ventilation had significantly less lung damage and inflammatory cell infiltration compared to the group that received no ventilation (measured by histological scores).
- - Despite showing benefits in lung protection, no significant differences were observed in overall hemodynamic stability between the two groups, indicating the need for more research to confirm these findings in clinical settings.
Background: Pulmonary hypertension in children often progresses despite optimal therapy. This document provides an evidence-based clinical practice guideline for the management of children with progressive pulmonary hypertension despite optimal therapy.
Methods: A multidisciplinary panel identified pertinent questions regarding the management of children with pulmonary hypertension that has progressed despite optimal therapy, conducted systematic reviews of the relevant literature, and applied the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach to develop clinical recommendations.
Article Synopsis
- The study investigates long-term survival outcomes for patients with severe ischaemic cardiomyopathy who underwent either coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) due to a lack of recent trial data.
- Using records from Australian and New Zealand cardiac registries between 2005 and 2018, researchers analyzed data from 2042 patients, with 1451 treated by CABG and 591 by PCI, adjusting for various risk factors.
- Results showed CABG patients had significantly lower long-term mortality compared to those who received PCI, although there were no differences in in-hospital mortality; however, CABG was associated with a higher risk of peri-procedural strokes and a longer hospital stay
Limitations of the inotrope score use as a measure of primary graft dysfunction.
J Heart Lung Transplant
October 2024
Allograft dysfunction is the major cause of early morbidity and mortality following cardiac transplantation. Poor graft function can be secondary to transplant complications or, when no identifiable cause is present, primary graft dysfunction (PGD). To standardize the definition of PGD, a consensus conference was convened which produced a document that defines severity categories and criteria for assessing left and right ventricular dysfunction.
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