Publications by authors named "D C McChesney"
Conventional spray drying using a 2-fluid nozzle forms matrix microparticles, where drug is distributed throughout the particle and may not effectively mask taste. In contrast, spray drying using a 3-fluid nozzle has been reported to encapsulate material. The objective of this study was to spray dry Eudragit® E-PO (EE) with acetaminophen (APAP), a water-soluble model drug with a bitter taste, using 2- and 3-fluid nozzles for taste masking.
View Article and Find Full Text PDFNisin ZP is an antimicrobial peptide (AMP) produced by the bacterium Lactococcus lactis, and we have previously demonstrated anticancer activity in NSCLC (A549) cells. In this study, we formulated a nisin ZP dry powder (NZSD) using a spray dryer to facilitate inhaled delivery for the treatment of NSCLC. Nisin ZP was spray-dried with mannitol, l-leucine, and trehalose in a ratio of 75:15:10 using Büchi mini spray-dryer B-290 in different drug loadings (10, 20, and 30% w/w).
View Article and Find Full Text PDFWhen a solitary liver mass is identified in a dog, a fine-needle aspirate (FNA) is commonly employed to attempt to obtain a diagnosis. Little information is provided in the literature evaluating the sensitivity/specificity of FNA cytology for solitary liver masses. We hypothesized that liver lesion size nor the presence of cavitation would impact the success of cytological diagnosis.
View Article and Find Full Text PDFArticle Synopsis
- The ongoing pandemic has significantly impacted the global economy, highlighting the importance of diagnostic testing in controlling virus spread and protecting public health.
- A new paper-based device using RT-LAMP allows for easy and visible detection of SARS-CoV-2 with just a simple heat source, making it suitable for use in low-resource settings.
- This testing platform is adaptable, enabling it to be reconfigured for various pathogens by changing primers, and it has potential applications in areas like food safety and animal diagnostics.
Article Synopsis
- A new paper-based device has been developed for detecting pathogen nucleic acids using a method called loop-mediated isothermal amplification (LAMP), providing visible color changes for easy identification.
- The device was specifically optimized to detect SARS-CoV-2 in human saliva within 60 minutes, achieving a high sensitivity of 97% and a specificity of 100%.
- It is designed with multiple reaction zones on special chromatography paper and can be adjusted to identify different pathogens by simply changing the LAMP primers used.