Publications by authors named "D C Link"
TP53 is mutated in 10 to 15% of cases of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) and is associated with a previous exposure to cytotoxic therapy, complex cytogenetic abnormalities, and a poor prognosis. Recent data have established the importance of TP53-mutant allele status, the determination of which requires specific genetic testing. Compared with monoallelic disease, multihit TP53-mutant AML/MDS is associated with chromosomal abnormalities and decreased overall survival.
View Article and Find Full Text PDFThis study explores whether referees are biased when awarding additional time in Association Football. We collected data on Awarded Additional Time (AAT) granted by the referees and Calculated Additional Time (CAT), representing the interruption time meant to be considered for additional time according to the rulebook. Analysis of Additional Time Error (ATE), given as the difference between CAT and AAT, in the second half of German football Bundesliga season 2022/2023, revealed that referees award less AAT than warranted by interruptions (ATE = 2:10 ± 2:24 min).
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- Zebra mussels are invasive species that can change aquatic ecosystems and food webs, potentially increasing mercury levels in fish, yet their impact in inland lakes hadn't been previously studied.
- In Minnesota lakes with zebra mussels, adult walleye and yellow perch showed mercury levels 72% and 157% higher, respectively, compared to lakes without them, with young fish also having elevated mercury concentrations.
- These higher mercury levels in invaded lakes raise concerns for fisheries management and human health, especially since many walleye exceeded safe consumption thresholds more frequently than in uninvaded lakes.
Sequential Decision Making in Beach Volleyball-A Mixed-Method Approach.
J Sport Exerc Psychol
October 2024
Which opponent player to sequentially serve to in beach volleyball is crucial given the advantage of the attacking team. The sequential choice theory was tested in three studies by analyzing allocation strategies based on the hot hand belief. Study 1 showed strong belief in the hot hand of national coaches.
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- Somatic mutations in hematopoietic stem cells (HSCs) can give these cells a survival advantage, particularly affecting a crucial chromatin modifier gene involved in blood cell formation.* -
- A study using a conditional loss of function model showed that this gene is vital for normal development of red and monocytic blood cells, revealing that HSCs lacking this gene fail to function properly despite having a normal number.* -
- The absence of this gene leads to increased DNA damage and stress in HSCs, activating the p53 pathway, which emphasizes its critical role in preserving HSC function and genomic stability during blood cell development.*