Cleft Lip and Palate Correction: The Utah Protocol.

Background: Cleft repair remains a contentious issue in craniofacial surgery, especially regarding the optimal timing and techniques. This study aims to present our institutions' current protocol for cleft lip and palate repair, including alveolar bone grafting (ABG).

Methods: A total of 17 patients (20 clefts) treated with the latest protocol from 2016 to 2023 were evaluated.

Advanced Management of Distal Lower Extremity Congenital Constriction Bands for Foot Salvage.

Constriction ring syndrome is a rare congenital condition characterized by the formation of fibrous amniotic bands, which can result in limb or digit deformation, malformation, or autoamputation. Surgical intervention is necessary for patients with progressive or severe forms of constriction banding, but the timing and operative approach vary widely. Here, the authors present a case report detailing the successful removal of multiple congenital constriction bands (CBs), uniquely affecting the distal ankle and foot in an infant meeting Patterson type-2 criteria.

Long-term changes in spatiotemporal distribution of Noctiluca scintillans in the southern North Sea.

To assess the spatiotemporal evolution of the heterotrophic dinoflagellate Noctiluca scintillans in the North Sea, the Helgoland Roads time series and Continuous Plankton Recorder survey were analysed using generalized additive models. Over the last decades, blooms of N. scintillans have occurred more frequently and intensively in many regions.

The impact of using time critical intervention-based dispatch thresholds on lowering lights and siren use to EMS 911 incidents.

Objectives: Emergency Medical Services (EMS) has historically utilized lights and sirens (L&S) to respond to 911 incidents. L&S are used in 86% of scene responses nationally; however, time critical interventions (TCIs) occur in less than 7% of these incidents. Responses with L&S are associated with increased risk of crashes and injuries.

Design and Discovery of a Potent and Selective Inhibitor of Integrin αvβ1.

Selective inhibition of the RGD (Arg-Gly-Asp) integrin αvβ1 has been recently identified as an attractive therapeutic approach for the treatment of liver fibrosis given its function, target expression, and safety profile. Our identification of a non-RGD small molecule lead followed by focused, systematic changes to the core structure utilizing a crystal structure, modeling, and a tractable synthetic approach resulted in the identification of a potent small molecule exhibiting a remarkable affinity for αvβ1 relative to several other integrin isoforms measured. Azabenzimidazolone demonstrated antifibrotic efficacy in an rat liver fibrosis model and represents a tool compound capable of further exploring the biological consequences of selective αvβ1 inhibition.