Publications by authors named "D C Javitt"
Article Synopsis
- * This chapter highlights the serial frequency discrimination task (SFDT), which assesses early auditory processing and learning, particularly in conditions like dyslexia and schizophrenia, by having participants compare pitches of paired tones.
- * The SFDT reveals important brain interactions, especially between cognitive control and perceptual regions, and informs the development of medications targeting N-methyl-D-aspartate receptors (NMDAR), potentially helping treat cognitive deficits in neuropsychiatric disorders.
The human visual system begins in the retina and projects to cortex through both the thalamocortical and retinotectal visual pathways. The thalamocortical system is divided into separate magnocellular and parvocellular divisions, which engage separate layers of the lateral geniculate nucleus (LGN) and project preferentially to the dorsal and ventral visual streams, respectively. The retinotectal system, in contrast, projects to the superior colliculus, pulvinar nucleus of the thalamus and amygdala.
View Article and Find Full Text PDFDeficits in cognitive control contribute to behavioral impairments across neuropsychiatric disorders. Cognitive control is captured as a construct in the Research Domain Construct (RDoC) matrix and incorporate subdomains of goal selection, response selection, and performance monitoring. Relevant tasks for these subdomains include the "AX" version of the continuous performance task (goal selection) and the Go/NoGo and Stop-Signal reaction time tasks (response selection).
View Article and Find Full Text PDFArticle Synopsis
- * Dysfunction in N-methyl-D-aspartate receptor (NMDAR) neurotransmission in the brain is thought to cause these issues, but there are currently no approved treatments targeting them.
- * Mismatch negativity (MMN) is being explored as a biomarker that can indicate early auditory processing dysfunction, linked to NMDAR issues, and may help in developing new pharmacological treatments for schizophrenia.
Article Synopsis
- The development of new treatments for neuropsychiatric disorders relies on accurate physiological measures that connect animal studies to human trials.
- Event-related potentials (ERP) are important for understanding cognitive impairments, with traditional ERP methods being used for patient classification and predicting outcomes.
- New time-frequency (TF-ERP) approaches offer more detailed insights and can improve the understanding of brain activity, potentially aiding in targeted therapies and personalized treatments for patients.