Publications by authors named "D C Hoffman"
Article Synopsis
- Aerosol contamination is a significant issue across various sectors, and the study focuses on using 3D-printed open foam-like lattice structures as an efficient solution for filtration.
- The researchers created and tested four different lattice geometries (Cubic, Kelvin, Octahedron, and Weaire-Phelan) to determine their effectiveness in capturing aerosol particles, finding that filtration performance improves with the specific surface area of the filter design.
- The study also identified mechanisms of particle deposition and established that 3D-printed lattices can achieve high filtration efficiencies (10-100%) under varying airflow conditions, indicating their potential as customizable and effective aerosol filters while addressing existing production challenges.
Patients with higher-risk myelodysplastic syndromes (HR MDS) have a median survival of ~1.5 years with azacitidine, and hematopoietic stem cell transplantation is their only curative option. Therefore, improved therapies are needed.
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- This study examined how two levels of low-intensity vibration training (0.6 g and 1.0 g) affected muscle and bone recovery in mice after a muscle injury known as volumetric muscle loss (VML).
- Mice were divided into groups receiving either no treatment or varying levels of vibration training for 15 minutes a day over 8 weeks post-injury.
- Results showed that bone structure improved with vibration training, particularly at the 1.0 g level, while muscle function showed less significant enhancement, suggesting that vibration training may be more beneficial for bone recovery than for muscle after VML.
Article Synopsis
- Peripheral nerve-crush injury promotes neuromuscular junction (NMJ) recovery, showing improved muscle function as nerve re-innervates, while volumetric muscle loss (VML) leads to permanent muscle function loss and chronic NMJ impairments.
- In a study with adult mice, researchers compared the effects of nerve-crush versus VML on NMJ remodeling, monitoring recovery over time post-injury.
- Results indicated that while nerve-crush injury allowed for complete recovery of muscle strength, VML resulted in persistent deficits, along with abnormal signaling and structural changes at the NMJ, with some noted sex differences in recovery rates.