Publications by authors named "D C Hesdorffer"
In this paper we look at non-pharmaceutical treatments for intractable epilepsy based on neurophysiological methods especially with EEG analysis. In summary, there are a number of limbic and thalamo-cortical related structures involved in the processing of musical emotion (exposure), including the amygdala (arousal, expression of mood, fear), hippocampus (memory, regulation of HPA axis, stress), parahippocampal gyrus (recognition, memory retrieval), insula (valence), temporal poles (connectivity), ventral striatum (expectation and experience of reward), orbitofrontal cortex (valence) and cingulate cortex (autonomic regulation). One method is to audify (a form of sonification) EEG activity to find music by feedback to entrain abnormal EEG activity.
View Article and Find Full Text PDFObjective: This study was undertaken to determine whether hippocampal T2 hyperintensity predicts sequelae of febrile status epilepticus, including hippocampal atrophy, sclerosis, and mesial temporal lobe epilepsy.
Methods: Acute magnetic resonance imaging (MRI) was obtained within a mean of 4.4 (SD = 5.
Hypothalamic hamartomas (HH) are rare, basilar developmental lesions with widespread comorbidities often associated with refractory epilepsy and encephalopathy. Imaging advances allow for early, even prenatal, detection. Genetic studies suggest mutations in and other patterning genes are involved in HH pathogenesis.
View Article and Find Full Text PDFObjective: To develop and validate a tool for individualized prediction of sudden unexpected death in epilepsy (SUDEP) risk, we reanalyzed data from 1 cohort and 3 case-control studies undertaken from 1980 through 2005.
Methods: We entered 1,273 epilepsy cases (287 SUDEP, 986 controls) and 22 clinical predictor variables into a Bayesian logistic regression model.
Results: Cross-validated individualized model predictions were superior to baseline models developed from only average population risk or from generalized tonic-clonic seizure frequency (pairwise difference in leave-one-subject-out expected log posterior density = 35.
Article Synopsis
- The study aimed to explore Interictal Dysphoric Disorder (IDD) in individuals with epilepsy and major depressive disorder (MDD) compared to those with MDD but no neurological conditions, challenging the idea that IDD is exclusive to epilepsy patients.
- Researchers analyzed data from 142 epilepsy patients and 222 controls, using various psychological assessments to evaluate the prevalence and characteristics of IDD, finding no significant differences between the two groups.
- The results indicated that IDD symptoms were similar in both groups, and while individuals with IDD experienced longer durations of affective disorders, the presence of epilepsy did not significantly correlate with IDD symptoms.