Publications by authors named "D C HARTMAN"
Article Synopsis
- * Out of 31 patients, 55% showed a significant drop in tumor activity (major pathologic response), along with increased immune cell presence in the tumors.
- * Findings indicate that this combination therapy not only activates various immune responses but is also linked to specific genetic markers in immune cells and changes in gut microbiota, suggesting potential pathways for enhancing treatment outcomes.
Article Synopsis
- Human environmental DNA (eDNA) shows promise as a forensic tool for detecting human DNA in aquatic environments but hasn't been thoroughly utilized yet.
- A preliminary study tested the persistence and detection of human eDNA using water samples from both freshwater and saltwater, with results indicating varying degrees of detectability over time.
- The findings suggest that incorporating human eDNA analysis could significantly aid law enforcement in improving investigation accuracy, especially in cases linked to aquatic settings, but further research is essential for optimization.
Article Synopsis
- The paper discusses the challenges of identifying human remains found at Sandy Point, Victoria, where both circumstantial information and preservation were lacking, complicating the identification process.
- Traditional methods like visual or fingerprint identification were impossible due to the state of the remains, leading to the use of a range of techniques including radiocarbon dating and genetic analysis.
- Ultimately, an interdisciplinary approach combining forensic anthropology, odontology, history, and genealogy successfully identified the remains as belonging to Christopher Luke Moore, who drowned in 1928.
The successful application of Forensic Investigative Genetic Genealogy (FIGG) to the identification of unidentified human remains and perpetrators of serious crime has led to a growing interest in its use internationally, including Australia. Routinely, FIGG has relied on the generation of high-density single nucleotide polymorphism (SNP) profiles from forensic samples using whole genome array (WGA) (∼650,000 or more SNPs) or whole genome sequencing (WGS) (millions of SNPs) for DNA segment-based comparisons in commercially available genealogy databases. To date, this approach has required DNA of a quality and quantity that is often not compatible with forensic samples.
View Article and Find Full Text PDFBackground: Almost half of patients with Crohn's disease (CD) require bowel surgeries in their lifetime. Due to the high risk of postoperative disease recurrence and high rate of previous antitumor necrosis factor (anti-TNF) failure, often alternative therapy options such as ustekinumab (UST) and vedolizumab (VDZ) are used. We aimed to evaluate the efficacy of UST and VDZ among postoperative CD patients as postoperative prophylaxis and rescue therapy.
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