Publications by authors named "D C Glahn"
Copy-number variants (CNVs) that increase the risk for neurodevelopmental disorders also affect cognitive ability. However, such CNVs remain challenging to study due to their scarcity, limiting our understanding of gene-dosage-sensitive biological processes linked to cognitive ability. We performed a genome-wide association study (GWAS) in 258,292 individuals, which identified-for the first time-a duplication at 2q12.
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- Schizophrenia (SCZ) shows differences in brain structure and symptoms between men and women, suggesting distinct neurobiological factors linked to sex.
- The study analyzed MRI data from nearly 6,000 participants to explore the effects of sex and diagnosis on the shape of deep brain regions in individuals with SCZ compared to healthy controls.
- Results indicated that women with SCZ had more pronounced shape abnormalities than men, but there were no significant interactions between diagnosis and sex, highlighting the need for further exploration of sex-related differences in schizophrenia's neurobiology.
Article Synopsis
- Research shows that gut dysbiosis is linked to psychiatric disorders like schizophrenia, but studies on adolescents with early-onset psychosis are scarce.
- This study found specific gut bacteria that are more or less abundant in schizophrenia patients compared to non-psychotic individuals, as well as variations based on the type of antipsychotic treatment they received.
- The analysis highlighted significant differences in enzymes related to fatty acid metabolism and identified differentially expressed genes, emphasizing the need to consider diet and gut microbiome in understanding the gut-brain connection in mental health.
Stress contributes to transdiagnostic morbidity and mortality across a wide range of physical and mental health problems. VR tasks have been validated as stressors with robust effect sizes for VR-based stressors to evoke stress across the most common autonomic and adrenocortical stress biomarkers. However, meta-analytic validation of VR stressors have resulted in inconsistent logic: why should something that isn't real evoke a very real suite of stress responses? This review posits that conceptually addressing this question requires differentiating a cause, "stressor", from effects, "stress".
View Article and Find Full Text PDFBackground: Early onset psychosis (EOP) frequently presents with a severe clinical phenotype and poor long-term prognosis. Clinical experience suggests that individuals with EOP have abnormal pain and somatosensory processing, yet relative to adult-onset psychosis, pain and somatic sensory processing in EOP have rarely been studied.
Methods: The history of two characteristic patients is described to illustrate clinical presentations of pain in EOP patients.