Publications by authors named "D C Feliciano"
Hepatic lipid accumulation, or Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), is a significant risk factor for liver cancer. Despite the rising incidence of MASLD, the underlying mechanisms of steatosis and lipotoxicity remain poorly understood. Interestingly, lipid accumulation also occurs during fasting, driven by the mobilization of adipose tissue-derived fatty acids into the liver.
View Article and Find Full Text PDFBrycon amazonicus is a species native to Brazil, with significant socioeconomic importance and immense potential for fish production. It is the second most cultivated species in the Amazon. The lack of specific molecular markers limits genetic research.
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- - The study questions the value of preoperative abdominopelvic CT scans (CTAP) in patients with gunshot wounds to the abdomen, as current guidelines recommend them but their practical usefulness is being debated.
- - Out of 149 patients analyzed, 72.5% showed clear signs for immediate surgical intervention (laparotomy), but CTAP findings only matched actual injury patterns in 57% of cases, missing significant injuries in 36.2% of patients.
- - The results suggest that while CTAP might clarify unclear injury paths, it rarely changes management strategies for patients needing surgery and can lead to unnecessary operations in some cases.
Enhancing End-of-Life Care With Home-Based Palliative Interventions: A Systematic Review.
J Pain Symptom Manage
November 2024
Context: Home-Based Palliative Care (HPC) interventions have emerged as a promising approach to deliver patient-centered care in familiar surroundings, aligning with patients' preferences and improving quality of life (QOL).
Objectives: This review aimed to systematically assess the impact of HPC interventions on symptom management, QOL, healthcare resource utilization and place of death among patients with severe, progressive illnesses requiring end-of-life care.
Methods: A comprehensive search was conducted across PubMed, Cochrane, and Scopus databases to identify relevant studies published between January 1, 2013, and December 31, 2023.
In vivo genetic modification of neural stem cells is necessary to model the origins and pathogenesis of neurological disorders. Electroporation is a technique that applies a transient electrical field to direct charged molecules into living cells to genetically modify the mouse brain. Here, we provide a protocol to electroporate the neural stem cells surrounding the neonatal ventricles.
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