Publications by authors named "D C Eaton"
Objective: Identify changes in general surgery resident autonomy and resident postgraduate year (PGY) level in Entrustable Professional Activity (EPA) cases over time.
Design: Retrospective cohort study.
Setting: United States Veterans Affairs (VA) hospital system, 2004 to 2020.
Background: Polymerase delta-interacting protein 2 (Poldip2) is a novel regulator of vascular permeability that has been shown to be involved in aggravating blood-brain barrier (BBB) disruption following stroke; however, the underlying mechanisms are unknown. While endothelial tight junctions (TJ) are critical mediators of BBB permeability, the effect of Poldip2 on TJ function has not been elucidated yet. Here, we aim to define the mechanism by which Poldip2 mediates BBB disruption, specifically focusing on phosphorylation and stabilization of the TJ integral protein ZO-1.
View Article and Find Full Text PDFAssessment of comorbid diseases is essential to clinical research and may risk-stratify patients for mortality independent of established methods such as the Charlson Comorbidity Index (CCI). In a retrospective study of U.S.
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- Socioeconomic deprivation negatively affects access to timely surgical care and quality measures for early-stage non-small cell lung cancer (NSCLC) among Veterans in the Veterans Health Administration (VHA).
- A study analyzed 9,704 Veterans with stage I NSCLC, revealing that those from areas of high socioeconomic deprivation were less likely to receive essential preoperative evaluations and timely surgery compared to those from less deprived areas.
- Post-surgery, Veterans in high deprivation areas had a higher risk of 30-day hospital readmission and were less likely to meet recommended care quality standards than their counterparts with lower deprivation levels.
Aflatoxins are mycotoxins produced by and several other related organisms and are common contaminants of numerous grains and nuts, especially maize (corn) and peanuts. Although, undoubtedly, aflatoxins have been present in the food of humans for millennia, their toxic effects were not discovered until 1960, first becoming evident as a non-infectious outbreak of poisoning of turkeys (Turkey X disease) arising from contaminated groundnut meal. The elucidation of specific chemical structures in 1963 led to the rapid characterization of aflatoxins as among the most potent chemical carcinogens of natural origin ever discovered.
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