Analysis of Glomerular Transcriptomes from Nephrotic Patients Suggest Risk Variants Impact Parietal Epithelial Cells.

The disproportionate risk for idiopathic proteinuric podocytopathies in Black people is explained, in part, by the presence of two risk alleles (G1 or G2) in the gene. The pathogenic mechanisms responsible for this genetic association remain incompletely understood. We analyzed glomerular RNASeq transcriptomes from patients with idiopathic nephrotic syndrome of which 72 had inferred African ancestry (AA) and 152 did not (noAA).

Does Fluoroscopic-Aided Enabling Technology Improve Acetabular Component Position and Reduce Radiation Exposure in Direct Anterior Total Hip Arthroplasty?

Accurate acetabular component positioning is crucial for the success of total hip arthroplasty (THA). Malplacement of the acetabular component increases the risk of post-surgery complications, most notably dislocation.1 Furthermore, malposition can also result in wear of the polyethylene liner, limited range of motion, and osteolysis.

Heteronemin suppresses EGF‑induced proliferation through the PI3K/PD‑L1 signaling pathways in cholangiocarcinoma.

Epidermal growth factor (EGF) binds with its surface receptor to stimulate gene expression and cancer cell proliferation. EGF stimulates cancer cell growth via phosphoinositide 3‑kinase (PI3K) and programmed cell death ligand 1 (PD‑L1) pathways. As an integrin αvβ3 antagonist, heteronemin exhibits potent cytotoxic effects against cancer cells.

Promoting psychological safety in simulation using a novel visual tool: A mixed-methods quasi-experimental study.

Background: Psychological safety is imperative for effective simulation-based learning within healthcare education, yet it is challenging for educators to establish. A visual tool, "Simulation Tool to Enhance Psychological Safety" (STEPS) was incorporated into simulation-based activities for prelicensure nursing students to support (or strengthen) psychological safety.

Objective: The purpose of this study was to determine the impact of the STEPS tool on psychological safety during simulated learning for prelicensure nursing students.