Publications by authors named "D C Conklin"

Article Synopsis
  • - This study explored whether there are health disparities in the prescription and use of menopause hormone therapy among perimenopausal and early postmenopausal women in the USA, by reviewing observational studies from 1940 until October 2023.
  • - Researchers found 16 different health disparities related to hormone therapy, noting significant differences based on ethnicity, education, medical conditions, and practitioner specialization.
  • - The findings indicate long-standing disparities in hormone therapy access and usage, highlighting the need for improved education for healthcare providers to better serve underserved populations.
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Electronic nicotine delivery systems (ENDS) aerosol exposures can induce endothelial dysfunction (ED) in healthy young humans and animals. Thermal degradation of ENDS solvents, propylene glycol, and vegetable glycerin (PG: VG), generates abundant formaldehyde (FA) and other carbonyls. Because FA can activate the transient receptor potential ankyrin-1 (TRPA1) sensor, we hypothesized that FA in ENDS aerosols provokes TRPA1-mediated changes that include ED and "respiratory braking"-biomarkers of harm.

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Article Synopsis
  • * New approaches in toxicology, particularly new approach methodologies (NAMs), aim to improve the ability to predict health hazards related to ENDS, taking into account factors like sex and race for better health equity outcomes.
  • * There’s a need for standardized methods to assess the health impacts of ENDS, as current limitations hinder regulatory efforts, making it essential to evaluate existing data sources for making informed decisions about public health risks.
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