Firsts in their field: the perceptions of women who have led the way.

The role women play in sport has been the subject of considerable discussion and research since the nineteen seventies. Much of this research has been descriptive or focused on the barriers, women face in advancing into a leadership role in a sporting organization. In an attempt to enrich the picture, women role models who occupy or have occupied leadership roles in sporting organizations were identified to gain their perspective, in their own words, on the challenges and requirements needed to be successful.

Structure-Based Discovery and Development of Highly Potent Dihydroorotate Dehydrogenase Inhibitors for Malaria Chemoprevention.

Malaria remains a serious global health challenge, yet treatment and control programs are threatened by drug resistance. Dihydroorotate dehydrogenase (DHODH) was clinically validated as a target for treatment and prevention of malaria through human studies with DSM265, but currently no drugs against this target are in clinical use. We used structure-based computational tools including free energy perturbation (FEP+) to discover highly ligand efficient, potent, and selective pyrazole-based DHODH inhibitors through a scaffold hop from a pyrrole-based series.

Ecological Dynamics as an Accurate and Parsimonious Contributor to Applied Practice: A Critical Appraisal.

With sport coaches adopting and working toward increasingly evidence-grounded approaches to practice, skill acquisition has appropriately become a critical area for consideration. As part of this growing interest in skill acquisition, the ecological dynamics approach has garnered attention amongst scholars and practitioners with myriad media (e.g.

The Professional Identity of STEM Faculty as Instructors of Course-based Research Experiences.

The professional identity of scientists has historically been cultivated to value research over teaching, which can undermine initiatives that aim to reform science education. Course-Based Research Experiences (CRE) and the inclusive Research and Education Communities (iREC) are two successful and impactful reform efforts that integrate research and teaching. The aim of this study is to explicate the professional identity of instructors who implement a CRE within an established iREC and to explore how this identity contributes to the success of these programs.

Investigating the consequences of chronic short sleep for metabolism and survival of oxidative stress.

In previous work, we found that short sleep caused sensitivity to oxidative stress; here we set out to characterize the physiological state of a diverse group of chronically short-sleeping mutants during hyperoxia as an acute oxidative stress. Using RNA-sequencing analysis, we found that short-sleeping mutants had a normal transcriptional oxidative stress response relative to controls. In both short-sleeping mutants and controls, hyperoxia led to downregulation of glycolytic genes and upregulation of genes involved in fatty acid metabolism, reminiscent of metabolic shifts during sleep.