An Abrupt Decline in Global Terrestrial Water Storage and Its Relationship with Sea Level Change.

Unlabelled: As observed by the Gravity Recovery and Climate Experiment (GRACE) and GRACE Follow On (GRACE-FO) missions, global terrestrial water storage (TWS), excluding ice sheets and glaciers, declined rapidly between May 2014 and March 2016. By 2023, it had not yet recovered, with the upper end of its range remaining 1 cm equivalent height of water below the upper end of the earlier range. Beginning with a record-setting drought in northeastern South America, a series of droughts on five continents helped to prevent global TWS from rebounding.

Building bridges from research outcomes to clinical practice decisions.

Practitioners may face difficulties implementing research results into practice. Seven examples of common knowledge translation barriers for clinicians are presented, and suggestions are offered for building effective communication bridges. Changes in how research results are reported and interpreted across different practice contexts can improve orthodontic care.

Compassionate access to virus-specific T cells for adoptive immunotherapy over 15 years.

Adoptive T-cell immunotherapy holds great promise for the treatment of viral complications in immunocompromised patients resistant to standard anti-viral strategies. We present a retrospective analysis of 78 patients from 19 hospitals across Australia and New Zealand, treated over the last 15 years with "off-the-shelf" allogeneic T cells directed to a combination of Epstein-Barr virus (EBV), cytomegalovirus (CMV), BK polyomavirus (BKV), John Cunningham virus (JCV) and/or adenovirus (AdV) under the Australian Therapeutic Goods Administration's Special Access Scheme. Most patients had severe post-transplant viral complications, including drug-resistant end-organ CMV disease, BKV-associated haemorrhagic cystitis and EBV-driven post-transplant lymphoproliferative disorder.

Bridging from research evidence to treatment decisions: The case of treatment based on predicted mandibular growth.

Introduction: Norms for mandibular growth are well-established, but they have large variances, and no research has been conducted on how practitioners use them in clinical judgment to guide the treatment of individual patients.

Methods: Co-Pog projections of mandibular growth were combined from the Burlington and Michigan growth studies following statistical adjustments. Cervical measures were also evaluated.