Publications by authors named "D C Bohan"
RNA interference is a natural antiviral mechanism that could be harnessed to combat SARS-CoV-2 infection by targeting and destroying the viral RNA. We identified potent lipophilic small interfering RNA (siRNA) conjugates targeting highly conserved regions of SARS-CoV-2 outside of the spike-encoding region capable of achieving ≥3-log viral reduction. Serial passaging studies demonstrated that a two-siRNA combination prevented development of resistance compared to a single siRNA approach.
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- - SARS-CoV-2 has evolved to evade current monoclonal antibodies (mAbs), emphasizing the need for more resilient treatments that can neutralize various viral strains.
- - A new human mAb called VIR-7229 has shown the ability to effectively neutralize multiple variants of SARS-CoV-2 and other related viruses, due to its unique targeting of a critical viral region known as the receptor-binding motif (RBM).
- - VIR-7229 demonstrates a high resistance to the emergence of virus escape mutants, making it a promising candidate for future therapies against evolving coronaviruses.
To date, evaluating the diets of natural enemies like carabids has largely been limited to spatially explicit and short-term sampling. This leaves a knowledge gap for the intra-annual dynamics of carabid diets, and the provision and timing of delivery of natural pest control services. Season-long pitfall trapping of adult carabids was conducted in conventional winter wheat fields, from November 2018 to June 2019, in five French departments.
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- * The oligosaccharyltransferase (OST) complex, particularly the STT3A/B enzymes, plays a crucial role in this glycosylation and has emerged as a promising target for broad-spectrum antiviral drugs.
- * The study highlights the balance between the antiviral potential of STT3A/B inhibitors, like NGI-1, and the need to assess their safety for humans, leading to the discovery of improved compounds that ensure both efficacy and lower toxicity risks.
Article Synopsis
- Intensified agriculture contributes to biodiversity loss, which negatively impacts ecosystem functions and their stability.
- A continental-wide study revealed that high agricultural intensity and simplified crop rotations decrease functional redundancy in seed predation across multiple weed genera.
- The research highlights that maintaining biodiversity is crucial for ensuring stable ecosystem functions, especially in intensively managed agricultural systems.