nSMase2-mediated exosome secretion shapes the tumor microenvironment to immunologically support pancreatic cancer.

The pleiotropic roles of nSMase2-generated ceramide include regulation of intracellular ceramide signaling and exosome biogenesis. We investigated the effects of eliminating nSMase2 on early and advanced PDA, including its influence on the microenvironment. Employing the KPC mouse model of pancreatic cancer, we demonstrate that pancreatic epithelial nSMase2 ablation reduces neoplasia and promotes a PDA subtype switch from aggressive basal-like to classical.

Impact of Sodium Alginate-Encapsulated Iron Nanoparticles and Soil Yeasts on the Photosynthesis Performance of L. Plants.

In a scenario of accelerated global climate change, the continuous growth of the world population, and the excessive use of chemical fertiliser, the search for sustainable alternatives for agricultural production is crucial. The present study was conducted to evaluate the plant growth-promoting (PGP) characteristics of two yeast strains, and , and the physicochemical characteristics of nanometric capsules and iron oxide nanoparticles (FeO-NPs) for the formulation of nanobiofertilisers. The physiological and productive effects were evaluated in a greenhouse assay using lettuce plants.

The Biosynthesis, Accumulation of Phenolic Compounds and Antioxidant Response in L. Plants Inoculated with a Biofertilizer Based on Soil Yeast and Iron Nanoparticles.

Lettuce is a vegetable that contributes vitamins, minerals, fibre, phenolic compounds and antioxidants to the human diet. In the search for improving production conditions and crop health, the use of microorganisms with plant growth-promoting capabilities, such as soil yeasts (PGPY), in conjunction with nanotechnology could offer sustainable development of agroecosystems. This study evaluated the synthesis of health-promoting bioactive compounds in lettuce under the application of soil yeast and an iron nanoparticle (NP-FeO) encapsulated in alginate beads.

Antioxidant Response, Phenolic Compounds and Yield of Tubers Inoculated with Arbuscular Mycorrhizal Fungi and Growing under Water Stress.

(potato) is one of the most common crops worldwide; however, it is sensitive to water stress, which necessitates the identification of alternative tools to improve their production. Here, we evaluated the inoculation of two arbuscular mycorrhizal fungi (AMF) strains, (CC), (HMC26), and the MIX (CC + HMC26) in yield and phenolic and antioxidant response using chromatographic and spectroscopic methods in potato crops, at increasing levels of water stress, namely, with 100% (0), 70% (S1), and 40% (S2) soil humidity. Two caffeoylquinic acid isomers were detected and their levels showed a tendency to increase under stress together with the AMF inoculation, reaching up to 19.

Towards the Clinical Translation of a Silver Sulfide Nanoparticle Contrast Agent: Large Scale Production with a Highly Parallelized Microfluidic Chip.

Ultrasmall silver sulfide nanoparticles (Ag S-NP) have been identified as promising contrast agents for a number of modalities and in particular for dual-energy mammography. These Ag S-NP have demonstrated marked advantages over clinically available agents with the ability to generate higher contrast with high biocompatibility. However, current synthesis methods are low-throughput and highly time-intensive, limiting the possibility of large animal studies or eventual clinical use of this potential imaging agent.