Adaptation of the Panama II strain of Plasmodium falciparum to Panamanian owl monkeys.

The Panama II strain of Plasmodium falciparum, acquired at the second passage level in splenectomized Colombian owl monkeys, was adapted to owl monkeys of Panamanian origin. Patent infections were induced in 22 of 27 unaltered and 20 of 21 splenectomized recipients during 19 serial passages. The infections were significantly more virulent in splenectomized than normal Panamanian owl monkeys, however recrudescences in seven normal monkeys achieved peak parasitemias 48 times greater than in the primary attack.

Studies with induced malarias in Aotus monkeys.

Aotus monkeys have been shown to be susceptible to the three most important species of human malaria as well as to simian, ape, and rodent malaria. The parasites natural to man were maintained by serial passages using trophozoite infected blood. It was then possible to transfer the infections to, and among, other New World monkeys which previously were refractory.