Publications by authors named "D Brophy"

Article Synopsis
  • A Phase II clinical trial examined the effects of intravenous vitamin C on patients receiving hematopoietic stem cell transplants to reduce nonrelapse mortality (NRM).
  • Patients (55 total) were given IV vitamin C for 14 days, which corrected their initial vitamin C deficiency and showed a trend towards lower NRM (11%) compared to historical controls (25%).
  • The study suggests that vitamin C repletion is safe and may improve survival rates (82% vs. 62%), but further randomized trials are necessary to validate these findings.
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Measurement of cortisol in fish scales is attracting considerable attention as a non-invasive indicator of chronic stress in wild populations. For many fish species of management and conservation interest, extensive scale collections exist that could provide extended records of individual stress responses, by combining cortisol measurements with life history information. However, it is not yet known how well cortisol is preserved in the scale during storage.

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Chylothorax, which accounts for 1% to 3% of pleural effusions, typically results from either surgery (traumatic) or underlying malignancy (nontraumatic). Less common causes of nontraumatic chylothorax are numerous and include congenital lymphatic abnormalities, connective tissue diseases, cirrhosis, and infection, among others. We describe what appears to be the first reported case of chylothorax caused by chylous ascites in Crohn disease.

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Fish scale microchemistry can be used to make life-history inferences, although ecological studies examining scale composition are relatively rare. Salmon scales have an external layer of calcium phosphate hydroxyl apatite (HAP). The structure, hardness, and calcium content of this layer have been shown to vary within and between species.

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Objectives: We previously demonstrated the potential of radiomics for the prediction of severe histological placenta accreta spectrum (PAS) subtypes using T2-weighted MRI. We aim to validate our model using an additional dataset. Secondly, we explore whether the performance is improved using a new approach to develop a new multivariate radiomics model.

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