Publications by authors named "D Brina"
Article Synopsis
- The study investigates how coagulation factor X (FX) impacts tumor growth in castration-resistant prostate cancer (CRPC) by examining the prostate tumor microenvironment in mouse models through single-cell RNA sequencing.
- It finds that immunosuppressive neutrophils (PMN-MDSCs) produce FX, which activates pathways that enhance tumor cell growth independent of androgens, indicating a role for FX in cancer progression.
- Targeting FXa could impede the oncogenic function of PMN-MDSCs and potentially improve treatment outcomes when combined with existing therapies, with high levels of FX and related markers correlating to worse survival in CRPC patients.
Article Synopsis
- Accumulating senescent cells contribute to aging and diseases, prompting research into botanical extracts for potential therapies that could target these issues.
- A standardized extract of Salvia haenkei (HK) was found to extend both lifespan and healthspan in aged mice by reducing inflammation and markers of senescence while improving muscle strength and fur quality.
- The study identified luteolin, a flavonoid in HK, as a compound that disrupts the interaction between the proteins p16 and CDK6, suggesting a mechanism through which HK promotes longevity by modulating cellular senescence.
Cancer is highly infiltrated by myeloid-derived suppressor cells (MDSCs). Currently available immunotherapies do not completely eradicate MDSCs. Through a genome-wide analysis of the translatome of prostate cancers driven by different genetic alterations, we demonstrate that prostate cancer rewires its secretome at the translational level to recruit MDSCs.
View Article and Find Full Text PDFTumor cells promote the recruitment of immunosuppressive neutrophils, a subset of myeloid cells driving immune suppression, tumor proliferation, and treatment resistance. Physiologically, neutrophils are known to have a short half-life. Here, we report the identification of a subset of neutrophils that have upregulated expression of cellular senescence markers and persist in the tumor microenvironment.
View Article and Find Full Text PDFArticle Synopsis
- - Researchers found that HER3, a protein often overexpressed in aggressive prostate cancer, is linked to faster progression to castration resistance and lower survival rates.
- - The study identified that NRG1, a ligand for HER3, is primarily produced by certain immune cells in the tumor environment, and its presence promotes cancer cell growth.
- - Targeting HER3 with specific therapies, like the antibody-drug conjugate U3-1402, shows promise in fighting HER3-positive prostate cancer, suggesting the need for further clinical trials.