Publications by authors named "D Bratu"
Processing bodies (P-bodies) are cytoplasmic membrane-less organelles which host multiple mRNA processing events. While the fundamental principles of P-body organization are beginning to be elucidated in vitro, a nuanced understanding of how their assembly is regulated in vivo remains elusive. Here, we investigate the potential link between ER exit sites and P-bodies in Drosophila melanogaster egg chambers.
View Article and Find Full Text PDFCell cycle progression is tightly controlled by the regulated synthesis and degradation of Cyclins, such as Cyclin A and Cyclin B, which activate CDK1 to trigger mitosis. Mutations affecting Cyclin regulation are often linked to tumorigenesis, making the study of cyclin mRNA regulation critical for identifying new cancer therapies. In this study, we demonstrate via super-resolution microscopy that and mRNAs associate with Bruno 1 and Cup in nurse cells.
View Article and Find Full Text PDFArticle Synopsis
- Age-related macular degeneration (AMD) is a major cause of blindness worldwide, and the use of intravitreal complement inhibitors is a promising treatment strategy that the review evaluates for geographic atrophy (GA) in AMD cases.* -
- The analysis included 18 studies covering 4272 patients, predominantly white females around 78 years old, revealing no significant visual function changes between patients receiving the treatment and control groups.* -
- While complement inhibitors show potential as a therapy for GA in AMD, the analysis suggests a need for personalized patient selection to enhance treatment outcomes.*
Background: Malignant tumors represent a significant pathology with a profound global impact on the medical system. The fight against cancer represents a significant challenge, with multidisciplinary teams identifying numerous areas requiring improvement to enhance the prognosis. Facilitating the patient's journey from diagnosis to treatment represents one such area of concern.
View Article and Find Full Text PDFAdvances in the study of mRNAs have yielded major new insights into post-transcriptional control of gene expression. Focus on the spatial regulation of mRNAs in highly polarized cells has demonstrated that mRNAs translocate through cells as mRNA:protein granules (mRNPs). These complex self-assemblies containing nuclear and cytoplasmic proteins are fundamental to the coordinated translation throughout cellular development.
View Article and Find Full Text PDF